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Treatment of recalcitrant pustular psoriasis with infliximab: effective reduction of chemokine expression

Treatment of recalcitrant pustular psoriasis with infliximab: Effective reduction of chemokine expression on ResearchGate, the professional network for scientists. Treatment of recalcitrant pustular psoriasis with infliximab: effective reduction of chemokine expression. Br J Dermatol 2004; 150:1009. To investigate anti-TNF-a induced psoriasis, we conducted a systematic analysis of the 6 cases we observed among our inflammatory patient cohort treated with anti-TNF-a (infliximab or etanercept). Recently, patients with palmoplantar pustulosis, when compared with healthy patients, were reported to have lower expression of TNF-a in the eccrine palmar sweat gland and in the skin. Benoit S, Toksoy A, Brocker EB, Gillitzer R, Goebeler M. Treatment of recalcitrant pustular psoriasis with infliximab: effective reduction of chemokine expression.

The epidemiology, pathogenesis, and clinical manifestations of pustular psoriasis will be reviewed here 2PPPP was observed in 2 patients treated with infliximab for symmetrical rheumatoid factor-positive RA; the patients had no personal or family history of psoriasis. T cells, which are strongly positive for CXCL8 and chemokine receptor CCR6, secrete CXCL8 and granulocyte macrophage-colony stimulating factor and could orchestrate neutrophil-rich pathologies such as pustulosis17. Infliximab can precipitate as well as worsen palmo plantar pustulosis: possible linkage to the expression of tumour necrosis factor alpha in the normal palmar eccrine sweat duct. M. Treatment of recalcitrant pustular psoriasis with infliximab: effective reduction of chemokine expression. However, paradoxically, manifestation of pustular psoriasis and plaque-type psoriasis has been reported in patients treated with TNF antagonists including infliximab for other indications. Benoit S, Toksoy A, Brocker EB, Gillitzer R, Goebeler M (2004) Treatment of recalcitrant pustular psoriasis with infliximab: effective reduction of chemokine expression. Treatment of von Zumbusch pustular psoriasis is a formidable task, especially when confounded by concomitant human immunodeficiency virus (HIV) infection. It is notoriously recalcitrant to treatment and may be life threatening. Benoit SToksoy ABrocker EBGillitzer RGoebeler M Treatment of recalcitrant pustular psoriasis with infliximab: effective reduction of chemokine expression.

Pustular psoriasis is a rare form of psoriasis that may require different approaches to treatment. Chimenti, S. Treatment of recalcitrant von Zumbusch pustular psoriasis with etanercept: P2753. Treatment of recalcitrant pustular psoriasis with infliximab: effective reduction of chemokine expression. The biologics available in India for the treatment of psoriasis are the tumor necrosis factor-alpha (TNF- ) antagonists-infliximab and etanercept. Biologic therapy is recommended only in recalcitrant cases of moderate to severe plaque psoriasis or variants of generalized psoriasis not responsive to conventional antipsoriatic therapies. This study postulates that site-specific factors or a differential contribution of immunological processes modulated by TNF- inhibitors to palmoplantar pustulosis and plaque-type psoriasis may be responsible for this expression. Treatment of recalcitrant pustular psoriasis with infliximab: Effective reduction of chemokine expression. FULL TEXT Abstract: BACKGROUND: Pustular psoriasis of the digits (acrodermatitis continua of Hallopeau) may be localized to one or more digits for over an extended. Treatment course included hospital admission, cyclosporine, acitretin, and discontinuation of cephalexin. She had a four year history of recalcitrant acrodermatitis which had been previously managed with numerous treatments including: steroid ointments & injections, calcipotriol/betamethasone ointment, acitretin, immunosuppressants (methotrexate and azathioprine), and PUVA hand soaks. Treatment of recalcitrant pustular psoriasis with infliximab: effective reduction of chemokine expression.

Full Text: New-onset Psoriatic Palmoplantaris Pustulosis Following Infliximab Therapy: A Class Effect?

Treatment of recalcitrant pustular psoriasis with infliximab: effective reduction of chemokine expression. We studied the effect of infliximab, a monoclonal antibody against TNF-alpha, on chemokine expression in pustular psoriasis. Reports of AntiTNF- Therapy in Patients With Pustular Psoriasis Source Patients, No.

References In Treatment Of Pustular Psoriasis: From The Medical Board Of The National Psoriasis Foundation