Skip to content

Treatment of inverse psoriasis with excimer therapy and tacrolimus ointment

Carrascosa, J. M., Soria, X., Domingo, H., & Ferrndiz, C. (2007). Treatment of inverse psoriasis with excimer therapy and tacrolimus ointment. Dermatologic Surgery, 33(3), 361-363. 10.1111/j.1524-4725.2007.33074.x. Numerous topical and systemic therapies are available for the treatment of the cutaneous manifestations of psoriasis. Topical calcipotriene or calcitriol and the topical calcineurin inhibitors tacrolimus or pimecrolimus are additional first-line treatments 8,9. Phototherapy (eg, excimer laser) and systemic agents are additional treatment options for patients who cannot achieve sufficient improvement with topical agents 10. Results. The recommended short-term (2-4 weeks) therapy for inverse psoriasis is low- to mid-potency topical steroids. For long-term therapy, topical calcipotriene (calcipotriol) or one of the immunomodulating agents, pimecrolimus or tacrolimus, is favored. 24Carrascosa, J.M., Soria, X., Domingo, H., and Ferrandiz, C. Treatment of inverse psoriasis with excimer therapy and tacrolimus ointment.

Treatment of inverse psoriasis with excimer therapy and tacrolimus ointment 23Wang, G., Li, C., Gao, T. et al, Clinical analysis of 48 cases of inverse psoriasis: A hospital-based study. 44Carrascosa, J.M., Soria, X., Domingo, H. et al, Treatment of inverse psoriasis with excimer therapy and tacrolimus ointment. She has remained in remission for up to 2 years, using only topical therapy with tacrolimus 0.1 and calcipotriol. There are few evidence-based studies on the treatment of inverse psoriasis involving genital flexion folds, and data reported related to the efficacy and safety are, so far, extremely limited and only supported by expert opinion (level of evidence 5 and recommendation class D) 1. Laser therapies (excimer, continuous carbon dioxide, erbium, pulsed dye laser) and UV phototherapy are commonly used for localized skin plaque psoriasis 47 50, except for YAG (yttrium aluminum garnet) laser, which has been shown not to improve localized plaque psoriasis 51. Treatment options for moderate to severe psoriasis include topical and systemic medications, phototherapy, and excimer laser, Combination therapies are often more effective than one treatment alone. One such medication, tacrolimus (Protopic), is an immunosuppressant that is proving to be useful in allergic skin disorders and is being studied for psoriasis.

Other types are guttate, inverse, erythrodermic, and pustular. Treatment options for moderate to severe psoriasis include topical and systemic medications, phototherapy, and excimer laser. Biologic drugs that target the root of the disease, the immune system, are the newest therapies considered in the treatment of psoriasis. Tacrolimus (Protopic) and Pimecrolimus (Elidel) are approved for the treatment of psoriasis. This retrospective case study evaluated the efficacy of tacrolimus 0.1 ointment to treat inverse psoriasis in children. OBJECTIVE: To determine the outcome in placebo-treated patients with plaque-type psoriasis. Speed and efficiency of available monotherapies tend to be inversely proportional to safety. New developments in the topical therapy and phototherapy of psoriasis have greatly improved our ability to safely and effectively treat this debilitating disease. Other drugs that are currently available include tacrolimus, mycophenolate mofetil, hydroxyurea, 6-thioguanine, and sulfasalazine. High-dose 308-nm excimer laser for the treatment of psoriasis.

References In Clinics In Dermatology

Treatment of inverse psoriasis with excimer therapy and tacrolimus ointment 3General Numerous topical and systemic therapies are available for the treatment of psoriasis. However, Guttate and flexural forms are particularly common in children and characterized by pruritic plaque lesions that are thinner, softener and less scaly than those seen in adults with most involvement of face and flexural area (5, 12). Most pediatric patients with childhood psoriasis can be effectively treated by topical therapies at home under supervision of their parents. In a study, topical tacrolimus 0.1 twice daily for four weeks was effective in the treatment of psoriasis (26). Recently, Xenon Chloride gas Excimer; a novel mode of phototherapy has been available, which can produce fluency wavelengths higher than UVB light used in localized dermatologic lesions and minimizing contact of body with UV radiation. Moderate and severe psoriasis are treated with combined topical and systemic therapy. A study by Li et al reported that 0.03 tacrolimus ointment in combination with and excimer laser treatment (308 nm) was more effective than tacrolimus alone. Psoriasis Reference guide covers causes, symptoms and treatments of this chronic skin disorder. Mainly affecting the skin in the armpits, in the groin, under the breasts and around the genitals, inverse psoriasis causes smooth patches of red, inflamed skin. Psoriasis treatments can be divided into three main types: topical treatments, light therapy and systemic medications.

Psoriasis