PDF Source for ‘Acute percutaneous salicylate intoxication is a rare event in children but can happen with a skin disease where salicylic acid, used as a keratolytic ointment, can be absorbed transcutaneously. Toxic inner ear damage in topical treatment of psoriasis with salicylates. Treatment of otic disease can be accomplished with the use of systemic or topical preparations. Autoimmune inner ear disease is a well described entity. The association between psoriatic arthritis and sensorineural hearing loss has not been described, although reports exist in the literature of toxic inner ear damage as a result of topical treatment of psoriatic arthritis with salicylates. U. Toxic inner ear damage in topical treatment of psoriasis with salicylates.
Useful in treating plaque psoriasis and scalp psoriasis, either alone or combined with other topical agents or treatment modalities. Because salicylic acid can irritate the skin, sodium salicylate is especially suitable for individuals with sensitive skin. Toxic inner ear damage in topical treatment of psoriasis with salicylates. Central nervous system toxicity includes, tinnitus, hearing loss and in very severe cases particularly in children convulsions and coma. It also possesses fungicidal properties and is used topically in the treatment of fungal skin infections such as tinea (Reynolds, 1996). High doses of salicylate have additional toxic effects on the central nervous system consisting of stimulation(including convulsions) followed by depression, confusion, dizziness, asterixis, delirium, psychosis, stupor and coma (Anderson et al. Detailed drug Information for salicylic acid Topical. Salicylic acid topical is used to treat many skin disorders, such as acne, dandruff, psoriasis, seborrheic dermatitis of the skin and scalp, calluses, corns, common warts, and plantar warts, depending on the dosage form and strength of the preparation. Salicylic acid may cause a serious condition called salicylate toxicity. Check with your doctor right away if you have nausea, vomiting, dizziness, loss of hearing, tinnitus, lethargy hyperpnea, diarrhea, and psychic disturbances.
Patient have information on symptoms, treatments and potential causes of psoriasis online. Psoriasis is a skin condition which tends to flare up from time to time. If severe, it can lead to hair loss in some people. One theory for this is that poisons (toxins) in cigarette smoke may affect parts of the immune system involved with psoriasis. Salicylic acid is a monohydroxybenzoic acid, a type of phenolic acid and a beta hydroxy acid. Sodium salicylate is commercially prepared by treating sodium phenolate (the sodium salt of phenol) with carbon dioxide at high pressure (100 atm) and high temperature (390 K) a method known as the Kolbe-Schmitt reaction. An injection of salicylic acid induced hearing loss in zinc-deficient rats, while a simultaneous injection of zinc reversed the hearing loss. A review of toxicity from topical salicylic acid preparations. Over-the-counter and prescription topical products like antifungal creams, ointments, and vitamin A compounds may be dangerous to your pets when licked. This is a prescription ointment containing vitamin D used to treat psoriasis. Do not put anything inside the cats ears, or any pet.
Treatment options for moderate to severe psoriasis include topical and systemic medications, phototherapy, and excimer laser, Combination therapies are often more effective than one treatment alone. Patches appear as red scaly areas on the scalp, behind the ears, above the shoulder blades, in the armpits or groin, or in the center of the face. When an injury or infection occurs, white blood cells are mobilized to rid the body of any foreign invaders, such as bacteria or viruses. Regular monitoring for liver toxicity includes blood tests and sometimes liver biopsies. What is a safe and effective treatment for psoriasis? June, age 50, presents with soft, raised, yellow plaques on her eyelids at the inner canthus. He needs a topical scrub to prevent Lyme disease d. If topical treatment is required and suitable, I always start with the lowest strength cortisone based ointment practical (eg hydrocortisone 1 ), because you can always increase if required, and it’s not going to cause too much thinning of the skin. We discovered eliminating foods high in salicylates and amines stopped the eczema on our 4 year old. As a boy I got eczema on the inside of the elbows, back of the knees, and also on the ankles and wrists. Keywords: hearing, iatrogenesis, ototoxicity, deafness, aminoglycosides. When salicylate acid is used for the treatment of psoriasis, there may be absorption of small quantities of salicylate by the skin, enough to cause a transient hearing loss. The toxic drug applied topically affects the middle ear through the perforation of the tympanic membrane, reaching the niche of the round window, on the medial wall of the middle ear, and it may contact the permeable wall of this window, the secondary tympanic membrane. The standard treatment is potent steroid creams applied 2-4 times per day. My skin is fragile inside my mouth.