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Topical Combination Maintenance Therapy for Psoriasis

Safe and effective long-term therapy is important when treating patients with psoriasis and maintaining remission of this condition. Various formulations of topical agents can provide safe and effective treatment of plaque psoriasis in most patients with limited disease. Medical treatment for localized psoriasis begins with a combination of topical corticosteroids and coal tar or calcipotriene. When the lesions have remained flat and the intensity of their color has declined from bright red to pink, the maintenance phase begins, with use of calcipotriene alone and discontinuation of the weekend use of topical corticosteroids. Calcipotriene in combination with Class I topical corticosteroids is highly effective for short-term control. Long-term maintenance therapy for psoriasis is required.

Topical Combination Maintenance Therapy for Psoriasis 2Combination topical therapy for the treatment of psoriasis. Continued application of calcipotriene ointment on weekdays supplemented by long-term clobetasol propionate foam pulse therapy on weekends appears to provide an enhanced maintenance of remission compared with calcipotriene monotherapy. Advances in topical treatments for psoriasis have kept pace with a rapidly evolving comprehension of its pathogenesis, making a review of current therapies useful for those who treat psoriasis. The combination of steroids and vitamin D analogues or topical retinoids is perhaps the most promising current treatment. Intermittent corticosteroid maintenance treatment of psoriasis: a double-blind multi-center trial of augmented betamethasone dipropionate ointment in a pulse dose treatment regimen. Given the reality that most psoriasis patients will use topical therapies, there has been increased attention paid to them in recent years. Like calcipotriol, topical calcitriol ointment will likely be used in combination with topical corticosteroids as an adjunct or a maintenance therapy.

Using a combination of treatments such as topical medications, systemic medications, biologics, and phototherapy can be useful for managing severe psoriasis. This is why most doctors prefer to treat psoriasis with a combination treatment plan. This involves gradually introducing a maintenance drug. To optimize the topical treatment of psoriasis in Saudi Arabia, the Saudi Society of Dermatology and Dermatologic surgery (SSDDS) have initiated a project to develop guidelines for the management of psoriasis. Combination of calcipotriol/betamethasone dipropionate ointment. Fumaric acid esters may be considered as an alternative maintenance therapy in patients who are not suitable for the above agents.

Combination Topical Therapy For The Treatment Of Psoriasis

Topical Combination Maintenance Therapy for Psoriasis 3In some cases, psoriasis can be hard to treat if it is severe and widespread. UV-B therapy may usually be combined with one or more topical treatments. Therapy is usually given two to three times per week on an outpatient basis, with maintenance treatments every two to four weeks until remission. Treatment options for moderate to severe psoriasis include topical and systemic medications, phototherapy, and excimer laser, Combination therapies are often more effective than one treatment alone. Combinations of oral treatments are particularly useful because the doses of each drug can be reduced. Psoriasis treatment regimens with CsA have to be adapted to the patient s needs and specific characteristics, after an accurate selection and a careful assessment of the risk/benefit ratio. As concerns the combination of CsA and topical drugs, which can be safely used to augment and accelerate the responsiveness to CsA, especially in regimens with low-dose CsA or while CsA dosage is tapering off, evidence exists for anthralin and calcipotriol alone or calcipotriol associated with betamethasone dipropionate as two-compound product (CBD). It may be used as monotherapy or in combination with topical or systemic therapies. Etanercept is given at a starting dose of 50 mg injected subcutaneously (SQ) twice weekly for 12 weeks followed by 50 mg once weekly for maintenance of moderate to severe chronic plaque psoriasis. Combination therapy for treatment of psoriasis and many other skin diseases is something we do routinely, but it is nice to know there is an evidence base that supports the benefits we see in clinical practice, says David M. Topical vitamin D analogues are almost always used to treat psoriasis in combination with a topical corticosteroid. In the latter study, patients were treated with the combination product for four weeks and then received maintenance therapy with either 1.

A Combination Treatment Plan For Severe Psoriasis