Development and validation of nail psoriasis quality of life scale (NPQ10). This study confirms a change in the quality of life of patients who have nail psoriasis. Development and validation of nail psoriasis quality of life scale (NPQ10). Conclusion This study confirms a change in the quality of life of patients who have nail psoriasis.
A number of studies have suggested that people with psoriasis may have an increased risk of cardiovascular disease, lymphoma and non-melanoma skin cancer. Nail changes are often seen, with pitting, onycholysis, subungual hyperkeratosis, or the oil-drop sign (yellow-red discolouration of the nail bed looking like a drop of oil beneath the nail). Skin biopsy is very rarely required to confirm diagnosis. Tools such as the Dermatology Life Quality Index may be helpful. Patients with nail psoriasis can develop a wide variety of nail ch. However, not all studies have corroborated this finding 9-12. More than one manifestation of nail psoriasis may be present in a single nail or in different nails in an individual patient. The physical changes in nail psoriasis are reviewed below:. The highest-quality evidence on nail psoriasis treatment resides in trials assessing biologic therapy. The authors concluded that in patients with psoriasis, fingernail disorders are mainly due to the psoriasis while toenail disorder changes can be associated with onychomycosis. If the parakeratosis is localized in the nail matrix, specific changes in the nail will result depending on localization and spreading in the matrix. The Dermatology Quality of Life Index is a measurement tool of patient responses to a simple 10-question validated questionnaire pertaining to their perceptions of their dermatological disease.
In addition to the psoriatic skin changes, it can affect the scalp and nails, causing pitting, ridging, and distal onycholysis. Some studies on psoriatic plaque have suggested enhanced humoral and cellular immunity to gram-positive bacteria; however, no direct relationship between bacteria and psoriasis has been proved. Diagnosis may be easier to confirm if psoriasis coexists with symptoms of arthritis. Randomized controlled trial of a water-soluble nail lacquer based on hydroxypropyl-chitosan (HPCH), in the management of nail psoriasis Franca Cantoresi,1 Maurizio Caserini,2 Antonella Bidoli,1 Francesca Maggio,1 Raffaella Marino,1 Claudia Carnevale,1 Paola Sorgi,1 Renata Palmieri21Department of Dermatology, Sapienza University, Rome, Italy; 2Scientific Department, Polichem SA, Lugano, Switzerland Background: Nail psoriasis occurs in up to 50 of patients affected by psoriasis, with a significant impact on quality of life that leads to a real clinical need for new therapeutic options. A bimodal age of onset has been recognised in several large studies. The difficulty of confirming psoriasis susceptibility loci may relate, in part, to heterogeneity among different populations. Nail involvement may be present, particularly if psoriatic arthritis (PsA) is present. Patients with psoriasis have a reduction in their quality of life similar to or worse than patients with other chronic diseases, such as ischaemic heart disease and diabetes.
Chronic Plaque Psoriasis. Symptoms, Causes And Treatment
8-10 Ustekinumab (CNTO 1275, Centocor)11,12 and briakinumab (ABT-874, Abbott Laboratories)13,14 monoclonal antibodies targeting the p40 molecule shared by interleukin-12 and interleukin-23 have shown clinical efficacy in patients with psoriasis. For the percentage change in the score on the Nail Psoriasis Severity Index, only patients with nonzero baseline scores were included in the analysis. The effect of severe psoriasis on the quality of life of 369 patients. Conclusions: Psoriasis has an immense impact on the life of patients and common comorbidities in psoriasis including coronary heart disease, depression, cerebrovascular disease, and metabolic syndrome. If patients change their behavior and attitudes, they can reduce stress and improve quality of life. This result confirms the moderating effect of the DLQI on the relationship between the PASI and GHQ-12 (Figure 2). Nail psoriasis as a severity indicator: results from the PsoReal study. The objective of this qualitative study was to better understand the impact of psoriasis symptoms using a 3-part process: 1) develop a disease model for psoriasis to identify the most important concepts relevant to psoriasis patients; 2) conduct interviews with dermatologists to identify key areas of clinical concern; and 3) explore psoriasis patients’ perceptions of the impact of psoriasis. Psoriasis has a major impact on health-related quality of life (HRQoL) that is comparable to other major medical diseases such as cancer, arthritis, hypertension, heart disease, diabetes, and depression 2, 3.