Psoriasis is a long-lasting autoimmune disease characterized by patches of abnormal skin. Infections and psychological stress may also play a role. Around one-third of people with psoriasis report a family history of the disease, and researchers have identified genetic loci associated with the condition. Those with a family history of psoriasis have an increased chance of having the disease. For example, a skin infection, skin inflammation, or even excessive scratching can trigger psoriasis. The word guttate is derived from the Latin word gutta, meaning dr. Learn more. Joint disease is associated with psoriasis in a significant proportion of patients (reported in one study to be 13. About 30 of patients with psoriasis have a family history.
Psoriasis is a common papulosquamous skin disease that may be associated with a seronegative spondyloarthropathy. Patients frequently have a history of a preceding upper respiratory tract infection or pharyngitis, particularly Group A Streptococcus. It binds and inactivates TNF and prevents its significant proinflammatory effects in the target tissue of skin and joints. A family history of psoriasis and stressful life events are also highly linked with the start of guttate psoriasis. A number of conditions may trigger pustular psoriasis, including infection, pregnancy, certain drugs, and metal allergies. Although EV-HPV is probably not a direct cause, it may play a role in the continuation of psoriasis. General features Although most diseases affecting the skin originate in the layers. Although there is some controversy over the causes of atopic dermatitis, the role of genetics is undisputed. Although psoriasis is neither infectious nor contagious it is disfiguring.
Guttate psoriasis is characterized by the acute onset of small, 1-10 mm diameter, droplike, erythematous-to-salmon-pink papules, usually with a fine scale, as demonstrated in the images below. The word guttate is derived from the Latin word gutta, meaning drop. Streptococcal perianal dermatitis, a superficial bacterial infection of the anus and perianal skin in children, has also been linked with the appearance of guttate psoriasis. A positive family history of psoriasis may be present. Triggering psoriasis: the role of infections and medications. Norrlind R. The significance of infections in the origination of psoriasis. With significant involvement of the skin, patients with erythrodermic psoriasis may need to be treated in a burn unit because of loss of fluid, electrolytes, protein, and disruption of normal body hemostasis functions. These clusters of pustules usually coalesce into larger areas as the disease progresses. Generally there is a family history of psoriasis that can help with the diagnosis, and the scale of scalp psoriasis is usually more white/silvery than the waxy, off-white/yellowish scale of seborrhea.
Psoriasis is not an infection, and it is not contagious. Immune system The immune system plays an important role in the skin changes that occur in psoriasis. It often affects children or young adults with no past history of psoriasis, and causes a sudden eruption of small scaly papules on the trunk of the body (picture 2). We failed to detect significant differences in streptococcal infection when comparing patients carrying HLA-Cw6 either alone or together with -B57 and/or -B13.