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The relationship between psoriasis and comorbidities remains controversial

Psoriasis is an inflammatory immune-mediated disease that affects the skin and has pathogenic effects with systemic impact. The relationship between psoriasis and comorbidities remains controversial. The hypothesis of a causative role of psoriasis in its cardiovascular and metabolic comorbidities is based on pathophysiologic concepts establishing a link between chronic inflammation in psoriasis, endothelial dysfunction, formation of atherosclerotic plaques, and the different compounds of metabolic syndrome. Additionally, pediatric psoriasis has been associated with certain comorbidities, such as obesity, hypertension, hyperlipidemia, diabetes mellitus and rheumatoid arthritis, making early diagnosis and management essential. Although a relationship between nail involvement and psoriatic arthritis in adults has been suggested, recent studies in both children and adults do not support this correlation 25, 32, 50. Although it is unclear whether weight loss reduces psoriasis severity in children, just as it remains controversial in adults, lifestyle education and weight-loss programs in these families should be recommended 11, 123. Hypertension is more often observed in patients with Pso as compared to a control population, although this association remains controversial (2).

The relationship between psoriasis and comorbidities remains controversial 2Therefore, since the association between psoriasis and COPD remains unclear and controversial among clinicians, a meta-analysis study was needed to further examine the correlation between psoriasis and COPD. Physicians should be aware of this potential risk to reduce comorbidity and mortality rates. Recent research has emphasized that psoriasis is a systemic disease with multiple associated comorbidities. However, the magnitude of this association remains controversial, and it is uncertain whether the increased risk for MACE is limited only to patients with severe psoriasis. To answer these questions, we performed a systematic review and meta-analysis of the association between psoriasis and cardiovascular death, MI, and stroke. Even though psoriasis etiology remains unknown, it is believed to be multifactorial with numerous key components including genetic susceptibility, environmental triggers in combination with skin barrier disruption and immune dysfunction. Perhaps the most detrimental aspect of psoriasis is the concurrent physical comorbidities such as cardiovascular disease (CVD), obesity, diabetes, metabolic syndrome, inflammatory bowel disease (IBD), and psoriatic arthritis that contribute to decreased longevity.

The psychological impact and comorbidity of psoriasis are often underestimated and can greatly impact on quality of life. Attention deficit hyperactivity disorder management options are evidence-based practices with established treatment efficacy for ADHD. The presence of comorbid (co-occurring) disorders can make finding the right treatment and diagnosis much more complicated, costly, and time-consuming. Unlike amphetamine, the difference in pharmacological properties between d-MPH and l-MPH is significant, as l-MPH is markedly inferior to d-MPH in its effects, which is due to a number of major differences between the isomers. The treatment of ADHD in the presence of tic disorders has long been a controversial topic. However, no studies have been reported regarding the severity of psoriasis, comorbidities, and concomitant medications on the risks of DM in patients with psoriasis. Thus, the relationship between psoriasis and DM remains controversial.

Plos One: Association Between Psoriasis And Chronic Obstructive Pulmonary Disease: A Systematic Review And Meta-analysis

Part one focused on atopic dermatitis and psoriasis.1 This second installment reviews alopecia areata, urticaria, and angioedema. It remains controversial whether the addition of an H2 receptor antagonist or a leukotriene antagonist is helpful. The secondary objective was to study the relationship between the duration and severity of the psoriasis and the MS. The cause of the disease remains unknown. 10.1111/j.1529-8019.2008.01217.xView Article; Christophers E: Comorbidities in psoriasis. The interplay between RA, ageing and (emerging) comorbidities is interesting but complex. The association of RA with accelerated atherosclerosis and eventually cardiovascular disease is a well-established one.

Psoriasis