It is well established that psoriasis and psoriatic arthritis (PsA) have a strong genetic component. Once a gene is identified, functional studies in biological systems are required to characterize the gene(s). 15 The only twin study in PsA to date confirmed that genes are important for psoriasis but did not have the power to detect a genetic effect in PsA. I region have also been investigated since the precise identity of the PSORS1 determinant has remained elusive due to the existence of strong linkage disequilibrium within this region, where at least nine genes with possible biologic significance have been associated with psoriasis HLA-B, HLA-C, PSORS1C3, OTF3, HCR, SPR1, SEEK1, corneodesmosin (CDSN), and TNF-. Psoriatic arthritis (PsA) is a chronic, systemic inflammatory disease. Compared with psoriasis patients who do not have PsA, psoriasis patients with PsA have greater QOL impairment, including physical and mental components of the 36-Item Short Form Health Survey 32, 34. Although the precise mechanism of action of sulfasalazine is unknown, it is thought to have anti-inflammatory effects mediated through inhibition of the 5-lipoxygenase pathway 139. Psoriatic arthritis (PsA) is a form of arthritis affecting individuals with psoriasis. Early diagnosis is essential in order to identify those who may develop more severe psoriatic arthritis and begin treatment that can prevent damage occurring to the joints. Topical medications for skin psoriasis such as vitamin D derivatives, although they may help the skin, have not been shown to benefit joints. They are safe when used in moderation and with precision.
The precise causes of psoriasis are unknown. However, psoriasis can develop in areas that have not been injured. Psoriatic arthritis (PsA), an inflammatory arthritis associated with psoriasis, has a wide spectrum of disease severity. In recent years, many genes that contribute to the pathogenesis of psoriasis and PsA have been identified, especially in Western cohorts. Psoriatic arthritis (PsA) is a heterogeneous disease with diverse clinical and radiographic manifestations. Ctrl, control; PsA, psoriatic arthritis; PsO, psoriasis where there is no arthritis.
Physical trauma, the so-called Koebner phenomenon, has been reported to induce the onset of psoriasis. Four groups have been identified: pauciarticular psoriatic arthritis, psoriatic spondylitis, symmetrical polyarticular psoriatic arthritis and arthritis mutilans. However, it was not until the 1960s that psoriatic arthritis (PsA) was distinguished clinically from rheumatoid arthritis (RA) 2 4. There has been a relative lack of research into PsA, especially when compared with other forms of inflammatory joint disease. There are still fundamental difficulties in establishing a precise definition for PsA, as we are hampered by the lack of specific diagnostic tests.
Psoriatic arthritis (PsA) is a chronic inflammatory skin disease that causes enthesitis and destructive arthritis and significantly lowers patient quality of life. Microbial infection has been known to trigger psoriasis and PsA. Th17 cells are a newly identified subset of helper T cells that produce interleukin- (IL-) 17A, IL-17F, IL-21, and IL-22 12 and differ functionally from Th1 and Th2 cells. Although immune responses mediated by IL-17 and IL-23 are not as apparent as with TNF-, Th17 cells appear to play an important role in PsA. Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with psoriasis. Approximately 7.5 million Americans have been diagnosed with psoriasis. The skin disease (psoriasis) and the joint disease (arthritis) tend to appear separately. As there are no serologic markers blood tests pathognomonic of PsA, it is most often a clinical diagnosis based on clinical history and morphologic characteristics of cutaneous lesions. Treatment options for moderate to severe psoriasis include topical and systemic medications, phototherapy, and excimer laser. Psoriasis has been linked to an increased risk of:. It is not clear whether psoriatic arthritis is a unique disease or a variation of psoriasis, although evidence suggests they are both caused by the same immune system problem. Symmetric PsA: Symptoms occur in the same location on both sides of the body. Psoriatic arthritis (PsA) is an inflammatory condition that leads to stiff, tender, and inflamed joints. The precise causes of psoriasis are unknown. The presence of a recently identified variation in a group of genes known as LCE can protect against the development of psoriasis. However, psoriasis can develop in areas that have not been injured.