Although nail psoriasis affects a substantial proportion of psoriasis patients and causes significant psychologic distress, few epidemiologic data characterizing patients with nail involvement are available. Nail involvement is associated with significant physical and psychological consequences for a substantial number of psoriasis patients.1 Prevalence data for nail involvement in psoriasis vary between 10 and 55. The nails are affected in a substantial number of patients with psoriasis. Background: Although nail psoriasis affects a substantial proportion of psoriasis patients and causes significant psychologic distress, few epidemiologic data characterizing patients with nail involvement are available. Patients with nail psoriasis were compared with patients without any nail involvement with regard to gender, age, disease duration, affected body surface area, health-related quality of life (Dermatology Life Quality Index DLQI ED-5D), patient-defined treatment benefit, amount of inpatient treatments, disease duration, and numbers of work days lost.
Psoriasis can affect both fingernails and toenails. For many people, nail psoriasis is often mild and causes few problems. Anecdotally, a number of dermatologists noticed that psoriasis of the nails improved when patients were using vitamin D analogue preparations for psoriasis of their skin. It’s worth noting that toenails can fail to respond where fingernails improve substantially. The documented prevalence of nail psoriasis varies between 100 and 811. Although the most striking clinical features of psoriasis involve the skin, other organs including nails and joints may be affected in a substantial proportion of patients. It mostly affects the skin and joints, but it also may affect the fingernails, the toenails, the soft tissues of the genitals and the inside of the mouth. Psoriasis can have a substantial psychological and emotional impact on patients. The prevalence of depression in patients with psoriasis may be as high as 50 percent.
Conjunctival impression cytology: Increased incidence of squamous metaplasia, neutrophil clumping, and snakelike chromatin. Intralesional corticosteroids: May be useful for resistant plaques and for the treatment of psoriatic nails. Nail psoriasis has significant adverse influence on the quality of life of many patients. The population-based Multinational Assessment of Psoriasis and Psoriatic Arthritis (MAPP) survey examined the impact of PsA on patients’ activities of daily living and unmet treatment needs. Patients with PsA reported a substantial impact of disease on physical function. Nail involvement typically occurs more often and is more severe in patients with PsA than in those with psoriasis alone and may predict the development of PsA in patients with psoriasis 10, 12, 16, 20, 24, 30, 35.
Nails are affected in the majority of patients with psoriasis at some point in their lives. Several systemic therapies can result in substantial improvement of psoriatic nails. Psoriasis of the nails associated with disability in a large number of patients: results of a recent interview with 1728 patients. In addition to the psoriatic skin changes, it can affect the scalp and nails, causing pitting, ridging, and distal onycholysis. Other studies have concluded this is not a substantial clinical problem. Although the most striking clinical features of psoriasis involve the skin, other organs including nails and joints may be affected in a substantial proportion of patients. Psoriatic arthritis can affect joints on the fingers and toes in characteristic ways that can be revealed through x-ray at a certain stage. The rheumatoid factor is usually absent in the blood of psoriatic patients. Asymmetric arthritis is associated with psoriatic nail changes of the finger. One exception to this might be when there is no substantial involvement of the fingers or toes. Yet, much of the world’s population finds psoriasis a trivial matter requiring little understanding or sympathy. A substantial proportion of psoriasis patients experience an inflammatory polyarthritis (psoriatic arthritis) that may include enthesitis, synovitis, tenosynovitis, periostitis, osteitis, sacroiliitis and spondyloarthritis. Special types include nail psoriasis, pustular psoriasis (localized to palms and soles, or generalized), psoriatic erythroderma, inverse psoriasis and various forms of palmo-plantar involvement. Psoriasis affects nearly three percent of the world’s population. TRANSFIGURE is the largest (N 198) and longest duration (132-week treatment period) randomized controlled study of a biologic in moderate-to-severe plaque psoriasis with significant nail psoriasis to report results to date.
Psoriasis: Practice Essentials, Background, Pathophysiology
The prevalence of psoriasis in the general population is estimated at 2-3. Tenosynovitis affects up to a third and nail changes are present in about two thirds. A number of different therapies have been administered for the treatment of nail psoriasis; however, there are no standardized therapeutic regimens. Substantial improvement of psoriasis on the right thumbnail after the first injection of ustekinumab. 1 The ring, middle and index fingers of the affected hand of patient No.