Most cases are not severe enough to affect general health and are treated in the outpatie. The mechanism of action of corticosteroids in psoriasis is not fully understood. Corticosteroids have anti-inflammatory, anti-proliferative, and immunosuppressive properties but their mechanism of action in psoriasis is not fully understood. Vitamin D analogues and topical corticosteroids are the most frequently used topical agents. The exact mechanism of action of UVB is not fully understood, but it is known to inhibit DNA synthesis and epidermal keratinocyte proliferation; induce T cell apoptosis, and induce immunosuppressive and anti inflammatory cytokines.
Psoriasis is a long-lasting autoimmune disease characterized by patches of abnormal skin. The underlying mechanism involves the immune system reacting to skin cells. The cause of psoriasis is not fully understood, but a number of theories exist. (topical steroid cream) can aggravate psoriasis due to the rebound effect. The etiopathogenesis of psoriasis is still not fully understood and involves a complex interaction of genetic and environmental factors. Although the exact mechanism of action of topical vitamin D analogs is not well understood in the treatment of psoriasis, their efficacy and safety has been shown in several clinical trials over the years and they are widely used for psoriasis. Therefore, combination of topical steroids and vitamin D analogs may be a logical option for the treatment of psoriasis. Nonetheless, the precise mechanism of action of vitamin D analogs in psoriasis is not fully understood.
Topical treatment with vitamin D analogs and corticosteroids is the mainstay of first-line therapy for patients with localized psoriasis. 7Although the exact mechanism of action of corticosteroids in psoriasis is not completely understood, corticosteroids are described to patients as anti-inflammatory agents that reduce the redness and swelling associated with psoriatic lesions. The mechanism of action of corticosteroids in psoriasis is not fully understood. Corticosteroids exert antiinflammatory, antiproliferative, and immunosuppressive actions by affecting gene transcription. The cause of psoriasis is not fully understood. The mechanism of action of each is probably different but they all help to normalise skin cell production and reduce inflammation. Abrupt withdrawal of some topical agents, particularly corticosteroids, can cause an aggressive recurrence of the condition.
Topical salicylic acid is also effective in treating chronic plaque psoriasis, especially when used as adjunctive therapy. 2,10 In addition, there is both in vitro and clinical evidence that salicylic acid augments the efficacy of concurrently used topical corticosteroid therapy for treating plaque psoriasis.2,10,11 In a study of patients with psoriasis comparing twice daily application of either monotherapy with fluocinonide 0. 1,2,7 Mechanisms of Action and Activity of Topical Salicylic Acid Although the mechanism of action of topical salicylic acid is not fully understood, available data suggest that three factors play a significant role. While the precise mechanism of keratolysis is not fully understood, it is thought that salicylic acid may reduce keratinocyte-to-keratinocyte binding as well as reduce the pH of the stratum corneum; these effects lead to reduced scaling and softening of psoriatic plaques. The functional role of LCs in psoriasis is not fully understood. A 22-year-old woman presents with a complaint of worsening psoriasis. Some topical anti-infectives contain corticosteroids in addition to antibiotics. Psoriasis treatments with medical marijuana and cannabis, research information. Ammonium compounds for treating psoriasis and eczema. Steroid compositions are used for the therapy of allergic diseases of type IV and such steroid compositions suppress the production of cytokine in T cells and show a -dramatic effect for the therapy of eczema. Though the exact mechanism of action of ammonia/ammonium salts/ quaternary ammonium compounds, such as ammonium chloride is not fully understood, actual testing on psoriasis patients have shown encouraging results without side effects associated with steroids and other presently available psoriasis topical applications.
Vitamin D Analogues And Corticosteroids In The Treatment Of Plaque Psoriasis
The composition according to claim 3, wherein the corticosteroid is clobetasol propionate. Further, as the cause of psoriasis is not fully understood, the treatment typically involves alleviating the manifesting symptoms rather than treating the underlying disease. While the mechanism underlying the synergistic mode of action still is to be revealed, a synergistic mode of action clearly is at hand.