Topical application of coal tar is one of the oldest therapies for atopic dermatitis (AD), a T helper 2 (Th2) lymphocyte mediated skin disease associated with loss-of-function mutations in the skin barrier gene, filaggrin (FLG). Despite its longstanding clinical use and efficacy, the molecular mechanism of coal tar therapy is unknown. These results indicate that coal tar enhances skin barrier function and dampens keratinocyte response to the major cytokines involved in AD, and point to a key role of the AHR signaling pathway in the molecular mechanism by which the oldest known drug in dermatology corrects epidermal abnormalities in a common skin disease. The primary cause of psoriasis remains unknown. Coal tar is available as an ointment, cream, lotion, shampoo, bath oil and soap. To optimize the topical treatment of psoriasis in Saudi Arabia, the Saudi Society of Dermatology and Dermatologic surgery (SSDDS) have initiated a project to develop guidelines for the management of psoriasis.
The topical coal tar has been used for the treatment of psoriasis long time ago (Slutsky et al. The mechanism of action of coal tar is exactly unknown but the possibility of suppression of DNA synthesis has been proposed producing the antiproliferative action in addition to the anti-inflammatory and keratolytic effects. Twin studies support the role of genetic factors with a three-fold increase in concordance in monozygotic twins compared with fraternal twins. Second-line therapy which includes phototherapy, broad-band or narrow-band ultraviolet B light, with or without supervised application of complex topical therapies such as dithranol in Lassar’s paste or crude coal tar and photochemotherapy, psoralens in combination with UVA irradiation (PUVA), and non-biological systemic agents such as ciclosporin, methotrexate and acitretin. Avoiding specific exacerbating factors may help to prevent or minimise flare-ups but the cause of disease exacerbation is often unknown. Psoriasis is a long-lasting autoimmune disease characterized by patches of abnormal skin. Ointment and creams containing coal tar, dithranol, corticosteroids (i.e. The mechanism of action of PUVA is unknown, but probably involves activation of psoralen by UVA light, which inhibits the abnormally rapid production of the cells in psoriatic skin.
Coal tar topical (for the skin) is used to treat the skin symptoms of psoriasis, including dryness, redness, flaking, scaling, and itching. It is not known whether coal tar topical will harm an unborn baby. It is not likely that other drugs you take orally or inject will have an effect on topically applied coal tar. Even though psoriasis etiology remains unknown, it is believed to be multifactorial with numerous key components including genetic susceptibility, environmental triggers in combination with skin barrier disruption and immune dysfunction. Medscape – Indication-specific dosing for Fototar, Medotar (coal tar topical), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.
Evaluation Of Therapeutic Effects Of Aloe Vera: Coal Tar Mixture In Psoriasis: An Immunohistochemical Study
Psoriasis is rare in infants and common in children and young age groups. The etiology of psoriasis is unknown. Reports of carcinoma in the site of local coal tar treatment is few but may occur. The mechanism of action may involve interference with arachidonic acid metabolism which is one of the major fatty acid components of fish oil. Psoriasis is an inflammatory disease that manifests most commonly as well-circumscribed, erythematous papules and plaques covered with silvery scales. Treatment can include emollients, vitamin D analogs, topical retinoids, tar, anthralin, corticosteroids, phototherapy, and, when severe, methotrexate, oral retinoids, immunomodulatory agents (biologics), or immunosuppressants. The mechanism of action is unknown, although UVB light reduces DNA synthesis and can induce mild systemic immunosuppression. Use topical treatments (eg, emollients, salicylic acid, coal tar preparations, anthralin, corticosteroids, vitamin D3 analogs, retinoids, calcineurin inhibitors, tazarotene), particularly for mild disease.