The effect of addition of calcipotriol ointment (50 micrograms/g) to acitretin therapy in psoriasis. on ResearchGate, the professional network for scientists. The efficacy of calcipotriol + acitretin combination therapy for psoriasis: comparison with acitretin monotherapy. The efficacy of calcipotriol + acitretin combination therapy for psoriasis: comparison with acitretin monotherapy.
Although their exact mechanism of action in the treatment of psoriasis is not completely understood, retinoids are known to modulate epidermal proliferation and differentiation and to have immunomodulatory and anti-inflammatory activity. One gram of ointment contains 0.05 mg (is equal to 50 micrograms) of calcipotriol. The following undesirable effects have been reported for calcipotriol cream, ointment and scalp solution during post-marketing experience: transient changes in skin pigmentation, transient photosensitivity reaction and hypersensitivity reaction including urticaria, angioedema, periorbital or facial oedema (very rarely). Topical preparations for the treatment of psoriasis: a systemic review.
The time necessary for a treatment to become effective is crucial for patients and physicians but has been largely neglected in the reporting and comparison of clinical trials in dermatology. Does adjuvant topical therapy benefit patients undergoing biologic therapy for psoriasis? To optimize the treatment of psoriasis in Germany, the Deutsche Dermatologische Gesellschaft and the Berufsverband Deutscher Dermatologen (BVDD) have initiated a project to develop evidence-based guidelines for the management of psoriasis.
Psoriasis: Recommendations For Retinoids
Addition of 10(-6)M acitretin at various times also revealed that its presence at cell culture initiation was necessary to inhibit proliferation significantly 20. Rapid effect of treatment of psoriatic erythrocytes with the synthetic retinoid acitretin to increase 8-azido cyclic AMP binding to the RI regulatory subunit 9.