However, the role of HLA genes as causative in the pathogenesis of the disease remains unclear. Strong association of HLA-Cw6 allele with juvenile psoriasis in Polish patients. The cause of psoriasis is still unknown although it is clear that there is a strong genetic component to the disease. Several of these cytokines are important in NK cell biology. Early studies examined a role for MHC genes (HLA in human) and identified HLA-Cw6 as a locus associated with psoriasis 47. HLA-Cw6 is one of the most associated alleles in psoriasis.
Although there is no cure for psoriasis, some biological therapies targeting specific immune components have recently proven to be highly effective 9. Th17 cells, which produce IL-17, were noted to play an important role in psoriasis 8. Within PSORS1, HLA-Cw6 is the primary allele associated with psoriasis 26. Psoriasis is an inflammatory skin disease of unknown origin, but with a clear genetic component. We could confirm a significant association between psoriasis and HLA-Cw6 odds ratio (OR) 7. In addition, there is some evidence for a biological role of the MHC S gene product in the pathogenesis of psoriasis. 05/9), which accounts for three distinct AAO groups tested at three loci, although this is probably still a conservative threshold. Genes and environment play a key role in the pathogenesis of these diseases. A strong HLA association is described for psoriasis, but not for atopic dermatitis. It is implicated in diverse aspects of epithelial membrane biology and immune synapse formation in T cells.
However, PSORS1 still contains genes that have not been characterized with regard to psoriasis. Sequence variants were detected by the TRACE_DIFF function. Data represent three biological triplicates as mean SD. While the cause of psoriasis remains unknown, it appears to result from a combination of genetic and environmental factors. Several agents listed (Past column), including corticosteroids and UV-B light, are still currently used by some dermatologists to treat psoriasis patients.
Biomarkers Of An Autoimmune Skin
These results underscore the essential roles of CDSN in hair physiology and suggest functional relevance of CDSN gene polymorphisms to psoriasis susceptibility. These include CDSNTTC, HLA-Cw6, and HCRWWCC. Psoriasis-like skin abnormalities in grafted skin from Cdsn-deficient mice. Alternatively, inflammatory changes in the epidermis caused by still-unknown mechanisms damage the desmosomal structures containing CDSN, which may contribute to the development of psoriatic pathology (25, 28). Biological Sciences. Psoriasis is a long-lasting autoimmune disease characterized by patches of abnormal skin. Infections and psychological stress may also play a role. The mechanism of action of PUVA is unknown, but probably involves activation of psoralen by UVA light, which inhibits the abnormally rapid production of the cells in psoriatic skin. Current data suggest that HLA-Cw6 is the susceptibility allele within PSORS1 9,30; The exact pathogenesis of psoriasis is still unknown.