Skip to content

TCR VDJ rearrangements in chronic psoriatic plaques indicates a common antigen in psoriasis vulgaris

Selection of conserved TCR VDJ rearrangements in chronic psoriatic plaques indicates a common antigen in psoriasis vulgaris. Eur. J. Immunol. 29, 3360-3368. Psoriasis: a T-cell-mediated autoimmune disease induced by streptococcal superantigens? TCR VDJ rearrangements in chronic psoriatic plaques indicates a common antigen in psoriasis vulgaris. The majority of epidermal T cells in Psoriasis vulgaris lesions can produce type 1 cytokines, interferon-, interleukin-2, and tumor necrosis factor-, defining TC1 (cytotoxic T lymphocyte) and TH1 effector populations: a type 1 differentiation bias is also measured in circulating blood T cells in psoriatic patients. Activation of dendritic antigen-presenting cells expressing common heat shock protein receptor CD91 during induction of psoriasis. Psoriasis vulgaris is the most common type of psoriasis, manifested as dry, red raised plaques with adherent silvery scales. The concept of superantigen was initially proposed based on several research findings where psoriasis patients had a restricted T-cell receptor (TCR) V usage in the peripheral blood and lesions. TCR VDJ rearrangements in chronic psoriatic plaques indicates a common antigen in psoriasis vulgaris.

TCR VDJ rearrangements in chronic psoriatic plaques indicates a common antigen in psoriasis vulgaris 2Psoriasis vulgaris is an inflammatory skin disease characterized by excessively increased keratinocyte proliferation. TCR VDJ rearrangements in chronic psoriatic plaques indicates a common antigen in psoriasis vulgaris. Psoriasis is one of the most common chronic inflammatory disorders with a strong genetic background. Fleischer B: T cells involved in psoriasis vulgaris belong to the Th1 subset. Cutaneous lymphocyte antigen-positive T lymphocytes preferentially migrate to the skin but not to the joint in psoriatic arthritis. The majority of epidermal T cells in Psoriasis vulgaris lesions can produce type 1 cytokines, interferon-gamma, interleukin-2, and tumor necrosis factor-alpha, defining TC1 (cytotoxic T lymphocyte) and TH1 effector populations: a type 1 differentiation bias is also measured in circulating blood T cells in psoriatic patients. TCR VDJ rearrangements in chronic psoriatic plaques indicates a common antigen in psoriasis vulgaris.

This approach is based on the prediction that antigen-driven T cell clonal expansion will result in molecular overrepresentation of the corresponding TCR idiotype. Selection of conserved TCR VDJ rearrangements in chronic psoriatic plaques indicates a common antigen in psoriasis vulgaris. T-cell repertoire analysis in chronic plaque psoriasis suggests an antigen-specific immune response. Altered keratin 17 peptide ligands inhibit in vitro proliferation of keratinocytes and T cells isolated from patients with psoriasis. TCR VDJ rearrangements in chronic psoriatic plaques indicates a common antigen in psoriasis vulgaris. Et al, Antigen analogs/MHC complexes as specific T cell receptor antagonists. Et al, HuMax-CD4: a fully human monoclonal anti-CD4 antibody for the treatment of psoriasis vulgaris. Psoriasis vulgaris (PsV) is a common inflammatory and hyperproliferative skin disease, affecting over 4 million Americans (about 2 ) at an estimated cost of 1. Whatever the nature of the antigen, entry of CD8+ T-cells into the epidermis would trigger more extensive epidermal hyperplasia, possibly by means of cytokines such as IL-17 and/or IL-22 produced by epidermal CD8+ T-cells 18-20; 24. TCR VDJ rearrangements in chronic psoriatic plaques indicates a common antigen in psoriasis vulgaris.

Unbound Medline

Selection of conserved TCR VDJ rearrangement in chronic psoriatic plaques indicates a common antigen in psoriasis vulgaris. Eur J Immunol. 1999;29:3360-3368.

Blood Journal