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Stress, the neuroendocrine system and mast cells: current understanding of their role in psoriasis

Stress, the neuroendocrine system and mast cells: current understanding of their role in psoriasis 1

Harvima IT, Nilsson G. Stress, the neuroendocrine system and mast cells: current understanding of their role in psoriasis. Expert Review of Clinical Immunology. Understanding how the activity of the psyche-nervous -immune system axis impinges on skin diseases Acute psychological stress is linked with mast cell activation and the release of IL-6. Conventionally, Langerhans cells have been considered pivotal for the generation of adaptive immunity although current studies suggest that their immunological activities may be considerably more complex (reviewed in 80 ). Harvima IT, Nilsson G. Stress, the neuroendocrine system and mast cells: current understanding of their role in psoriasis. Expert Rev Clin Immunol. 2012 Mar;8(3):235-4 2.

Stress, the neuroendocrine system and mast cells: current understanding of their role in psoriasis 2Stress, the neuroendocrine system and mast cells: current understanding of their role in psoriasis. Ilkka T Harvima and Gunnar Nilsson. Expert Review of Clinical Immunology (2012) 8:235 Link to Article. Stress, the neuroendocrine system and mast cells: current understanding of their role in psoriasis. 2 in skin inflammatory diseases and release of IL-8 upon PAR-2 activation.

Harvima, I.T. and Nilsson, G. (2012) Stress, the neuroendocrine system and mast cells: Current understanding of their role in psoriasis. Expert Review of Clinical Immunology, 8, 235-241. Previous reports addressing its influence on skin psoriasis and chronic urticaria have been mainly anecdotal. The new multidisciplinary field of psychoneuroimmunology has investigated the role of endocrine, nervous, and immune systems. In humans, stress results in decreased levels of natural killer-cell cytotoxicity, depressed mitogenic responses in lymphocytes, increased serum immunoglobulin A levels, enhanced neutrophil phagocytosis, and activation of interferon synthesis in lymphocytes. Overall, these results support the view that psychological stress plays a significant role in triggering or exacerbating dermatological diseases. Harvima IT, Nilsson G. Stress, the neuroendocrine system and mast cells: current understanding of their role in psoriasis. Expert Rev Clin Immunol.

Journal Of Molecular Endocrinology

Stress, the neuroendocrine system and mast cells: current understanding of their role in psoriasis 3Hence, in this review the current understanding of the role of cutaneous mast cells and sensory nerves and their activation in psychic stress is discussed. Association of stress with psoriatic skin symptoms was studied in 13 patients with psoriasis by dividing the patients into low-and high-stress groups based on their clinical examination and answers to. Current Issue; vol. Mast cells are also increased in lesional psoriatic skin (13) and there appears to be an association among sensory nerves, mast cell numbers, and stress (13, 14). We also used inhibitors of the ERK, JNK, and p38 pathways to investigate their role in SP-induced VEGF release from LAD2 cells. Immunohistochemical staining was performed using the LSAB+ system kit (DAKO). NK-1 is also important in stress-induced murine skin mast cell activation (3, 16), and in the development of atopic dermatitis in mice (68). The current understanding, therapeutic options, and open questions of the role that neuropeptides such as substance P, calcitonin gene-related peptide, vasoactive intestinal peptide/pituitary adenylate cyclase-activating polypeptide, neuropeptide Y, or others play in these events are discussed.

Influence Of Maternal Experimental Hypothyroidism On Quantitative-qualitative Indicator Of Rat Progeny Skin Mast Cells In Age Aspect According To Histochemical Investigation Results And On The Base Of Lectins Gna And Pna Receptors Cytotopography