By recognizing cutaneous manifestations of systemic diseases, the internist can often determine the appropriate diagnosis and therapy or the need for referral to a dermatologist. Differential diagnosis includes psoriasis, atopic dermatitis, allergic or irritant contact dermatitis, and dermatophyte (tinea) infections. Differential diagnosis includes erythema multiforme, deep fungal infection, pyoderma gangrenosum, and cutaneous metastases. As for therapeutic application in dermatology, MPA was first used successfully in treating psoriasis in 1975. What is unique about the mechanism of action of mycophenolate mofetil, which results in lymphocyte-specific effects? Of the connective tissue disorders, lupus erythematosus (LE) and dermatomyositis have received the most attention regarding off-label use of MMF. Other reported dermatological uses of MMF include graft-versus-host disease, cutaneous vasculitis, scleroderma, recurrent erythema multiforme, erythema nodosum, lichen planus, cutaneous Crohn’s disease, sarcoidosis, and pyoderma gangrenosum. With an improved side-effect profile and enhanced bioavailability, MMF is a promising drug for immune-mediated skin disease.
Inflammatory skin disorders, also inflammatory skin diseases, are a significant part of dermatopathology. 3.4 Dermatomyositis 3. Psoriasis vulgaris (most common). DDx: systemic lupus erythematosus, lichen planus, and graft-versus-host disease. DDx:. 11611), lack of spongiosis rules out eczema (& with the exception of atopic dermatitis and lichen simplex chronicus 22). Nipple, breast: be alert for Paget’s disease, almost all of which cases have an underlying breast cancer. cutaneous lymphoma40: look for MF-type changes. Papillary dermal edema and often heavy superficial & deep perivascular infiltrate more polymorphous than lupus (not just lymphs PD13-2541 ). Patchy yellow or brown collagen discoloration: leprosy drug, cofazimine (also used in SLE, pyoderma gangrenosum, & Melkersson-Rosenthal syndrome23). This disease can affect the tongue, intestines, skeletal and smooth muscles, nerves, skin, ligaments, heart, liver, spleen, and kidneys. Behcet’s disease is a chronic, multisystem autoimmune disease involving inflammation of blood vessels, called vasculitis, throughout the body. Other disorders linked to this condition include leukemia, lymphoma, sarcoidosis, rheumatic fever, Bechet’s disease, and ulcerative colitis. If lichen planus is caused by a medicine you are taking, the rash should go away once you stop the medicine.
Specifically, psoriasis, lichen planus, cutaneous lymphoma, vasculitis, lupus, dermatomyositis,scleroderma, and pyoderma gangrenosum. Dr. Heffernan is an expert in the treatment of complex dermatologic conditions, especially the biologic drugs. Psoriasis is a common, chronic, and recurrent inflammatory disease of the skin characterized by circumscribed, erythematous, dry, scaling plaques. Pyoderma gangrenosum. The specific dermatoses of pregnancy. The underlying assumption of such a chapter is that the clinician has been able to identify the specific disorder in the patient and needs only to read about it in the textbook.
Inflammatory Skin Disorders
Psoriasis formis type – looks very much like psoriasis so take biopsy before photoradiation therapy to be sure. Uv light can be a trigger to go into sle 70: Anti-rho/ssa and anti-ssb Neonatal scle??. Systemic Scleroderma. Diseases in which the primary pathology involves the dermo-epidermal junction. Lupus. Dermatomyositis. Lichen planus. Erythema multiforme. Ana specific for sle. Pyoderma gangrenosum dx. Infectious, vasculitis, ulcer, lymphoma, scc. What therapy has been tried? dose, duration, frequency of actual use Contacts (where appropriate): Pets or farm animal contact, travel, motel stays PMHx: Diabetes, hypertension, atopy (eczema, asthma, hay fever), previous skin cancers or other skin problems; STDs, HIV, blood transfusions Medications: Dosage listed for any derm drugs; specific topical steroid names Allergies (& specific reaction) Habits: Smoking, alcohol, drug abuse FamHx: Psoriasis, melanoma, atopy, genetic conditions (e. Keratosis pilaris Lichen planus Melanoma Nevus Psoriasis Pyoderma gangrenosum Seborrheic keratosis Stasis dermatitis Ulcer Vasculitis Dermatoses by Location 02Barankin(F)-02 3/28/06 12:12 PM Page 15. Skin Disease: Diagnosis and Treatment, 3rd Edition, by Drs. Thomas P. Habif, James L. Campbell, Jr., M. Shane Chapman, James G. Misdiagnosis of Lupus including hidden diseases, diagnosis mistakes, alternative diagnoses, differential diagnoses, and misdiagnosis. Psoriasis often undiagnosed cause of skin symptoms in children: Children who suffer from the skin disorder called psoriasis can often go undiagnosed. Rheumatoid arthritis and muscle inflammation may also coexist Some patients develop lupus-like symptoms as well as symptoms of other disorders such as rheumatoid arthritis, scleroderma or dermatomyositis but lupus cannot be definitively diagnosed.