(chronic plaque psoriasis), accounting for 85-90 of all cases of psoriasis. Psoriasis is a chronic skin inflammatory disease which is now considered a systemic immunomediated disorder. There are several different types of psoriasis the most common, psoriasis vulgaris, accounts for 8090 of all psoriasis cases. Psoriasis vulgaris (also known as chronic plaque psoriasis) is characterised by raised, rough plaques with surrounding normal skin. Clinicians use a specific method to assess severity of psoriasis, called the Psoriasis Area and Severity Index (PASI).
However, a reliable and simple stratification of clinical presentation of psoriasis is lacking. Figure 1 Characteristic histological features of psoriatic plaques. 126, 1523 (1990). In the case of at least the susceptibility locus at 17q25, the development of psoriasis does not require the presence of HLA-Cw6. Although the skin disease psoriasis was first recognized as a distinct disease as early as 1808 (1), its pathogenic mechanisms have eluded investigators for decades. Although considerable progress has been made in understanding the phenotype of psoriasis at the cellular and molecular levels, many questions remain unresolved.
Norwegian scabies resembling a psoriasis plaque on the arm. Psoriasis is a chronic papulosquamous skin disease that is thought to be a T-cell-mediated autoimmune disorder of keratinocyte proliferation. HIV-associated psoriasis can be clinically confusing because several comorbid skin disorders in patients with HIV can mimic psoriasis. Psoriasis is recognized as a complex disease for which multiple genetic and non-genetic factors influence susceptibility. Psoriasis is a chronic inflammatory skin disease. The clinical presentation of psoriasis can range from the more common red scaling elevated plaques on the elbows, knees, or scalp to the less common superficial pustules scattered on the palms or soles, or in rare cases wide-spread pustules on the body. More specifically, the clinical spectrum of psoriasis includes the plaque, guttate, small plaque, inverse, erythrodermic, and pustular variants.
A Classification Of Psoriasis Vulgaris According To Phenotype