Average age being 47,14 (SD15,41) years, from that there were 36 men or 51,43 and 34 women or 48,57. RESULTS: The incidence of metabolic syndrome in patients with psoriasis was 38,57. (29) The increased prevalence of metabolic syndrome among patients with psoriasis has been replicated in multiple countries including Italy, Israel, India, Japan, China, Tunisia, and the United States. (38, 39) Finally, emerging data suggest that the association of psoriasis with metabolic syndrome occurs early in the course of the disease as psoriasis is associated with obesity and elevated lipids even in childhood. These results suggest that psoriasis severity is a driving factor behind metabolic disorders so frequently seen in this patient population, or alternatively, that metabolic disorders lead to worsening severity of psoriasis. Charlson Comorbidity Index Score by Psoriasis Severity+View Large Save Table Download Slide (.
HDL levels ranged from 30 to 60 mg/dl in cases and 32 to 57 mg/dl in controls. Obesity was reported to be a risk factor for psoriasis development as well as to be correlated with psoriasis activity1, 2. In the case group, we included 38 patients on cyclosporine (4 mg/kg/d). J Dermatol Sci 2010;57:143144. 14. Results from the current mortality studies in PsA yield conflicting findings 3, 817 (Table 1). The prevalence of diabetes mellitus was also found increased in PsA in the majority of 22, 34, 43, 45, but not in all 20, 21 of the previous studies.
Results MetS was seen in 62.9 (17) of patients with PsO and in 32.8 of patients with PsA. They found that the incidence of psoriasis among total skin patients ranged between 0. So, the results of various studies suggest that psoriasis is definitely a pruriginous disorder adding to the morbidity of this dermatosis. Associations There are several associations of psoriasis including arthritis, immunobullous disorders, vitiligo, metabolic syndrome and synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome. Metabolic syndrome is a clustering of at least three of five of the following medical conditions: abdominal (central) obesity, elevated blood pressure, elevated fasting plasma glucose, high serum triglycerides, and low high-density lipoprotein (HDL) levels. The approximate prevalence of the metabolic syndrome in patients with coronary heart disease (CHD) is 50, with a prevalence of 37 in patients with premature coronary artery disease (age 45), particularly in women.
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Because of increased prevalence of cardiovascular co morbidities in patients with psoriasis, dermatologists should consider the disease as a possible multisystem disease and warn these patients for the prospective negative effects of their disease. Cardiovascular disease, psoriasis, metabolic syndrome, inflammation, psoriasis. The risk of mortal- ity in patientswith psoriasis: results from a population- based study. J Am Acad Dermatol 2007: 57: 34754. Int J Dermatol 38:241-51, 1999. Keywords: Psoriasis, Metabolic syndrome, Comorbidities. (VEG-F), estn elevados en la psoriasis, la obesidad y la enfermedad coronaria38,39. 2010;57:143-4. The risk of mortality in patients with psoriasis: Results from a population based study. Up to 4-fold increase in the prevalence of metabolic syndrome and 3-fold increased risk of cardiovascular mortality is reported globally in psoriatics. More specifically obesity, rather than being a result of insulin resistance, leads to its increased causation in these individuals. 38. Padhi T, Garima. Metabolic syndrome and skin: Psoriasis and beyond. One incidence study found that psoriasis patients have a hazard ratio of 1. 4, 5, 6, 7 Understanding the epidemiological relationship between psoriasis and obesity is also important for delineating risk factors for other comorbid diseases that may result from obesity. Results: Of the 23 variables, the PASI was significantly associated with education and habit of drinking alcohol (P. Conclusions: Psoriasis has an immense impact on the life of patients and common comorbidities in psoriasis including coronary heart disease, depression, cerebrovascular disease, and metabolic syndrome. Screening for these comorbidities in psoriasis patients is essential. The severity of psoriasis frequently changes, as does the psychiatric and clinical profile of the patient, and both may affect quality of life.24,27,57 Demographic characteristics and lifestyle have a definite bearing on the manner in which the disease behaves and its treatment and prognosis.