In this 3-part series on psoriasis, first, I’m going to update you on the diseases linked to psoriasis, called psoriasis comorbidities. Second, I’m going to give you actionable steps to help keep your skin and body healthy. Psoriasis is a long-lasting autoimmune disease characterized by patches of abnormal skin. Recently, the first gene directly linked to psoriasis has been identified. A rare mutation in the gene encoding for the CARD14 protein plus an environmental trigger was enough to cause plaque psoriasis (the most common form of psoriasis). Treatment options for moderate to severe psoriasis include topical and systemic medications, phototherapy, and excimer laser, Combination therapies are often more effective than one treatment alone. These same variations linked to psoriasis and psoriatic arthritis are also associated with four known autoimmune diseases: type 1 diabetes, Grave’s disease, celiac disease, and rheumatoid arthritis, suggesting that all of these diseases have the same genetic basis.