Quality of Life and Psychosocial Factors Associated With Severe Psoriasis Following Treatment With Adalimumab (Body Image). This study seeks to explore if adalimumab treatment of psoriasis leads to a positive impact on psychosocial factors and disease-related quality of life. (a biologic agent) has on quality of life, body image and psychosocial factors. Life Quality Index DLQI) after 16 weeks of adalimumab treatment. Quality of Life and Psychosocial Factors Associated With Severe Psoriasis Following Treatment With Adalimumab. Hospital Anxiety and Depression Scale (HADS), Cutaneous Body Image (CBI) scale, Short Form 12 (SF-12) Health Survey, Female Sexual Function Index (FSFI) (female participants) and International Index of Erectile Function (IIEF) (male participants) questionnaires were completed by participants and at 4 weeks, 16 weeks and 6 months following initiation.
Quality of Life and Psychosocial Factors Associated With Severe Psoriasis Following Treatment With Adalimumab. Psoriasis is associated with a variety of psychological difficulties, including poor self-esteem, sexual dysfunction, anxiety, depression, and suicidal ideation. A Real World Observational Study to Evaluate the Impact of Adalimumab Therapy on Quality of Life and Psychological Factors Associated With Severe Psoriasis.
Factors associated with quality of life in psoriasis patients are described. Psoriasis patients often experience difficulties like maladaptive coping responses, problems in body image, self esteem, self concept and also have feelings of stigma, shame and embarrassment regarding their appearance 8. These studies have highlighted the need for psychosocial strategies in treating patients with psoriasis and helping them to improve their overall QoL. Comparable improvement in HRQoL with short contact dithranol treatment and UVB phototherapy, inpatients experienced a more impaired HRQoL and showed no significant improvement in HRQoL directly following treatment. Drug focus: adalimumab in the treatment of moderate to severe psoriasis. Psoriasis has a relevant influence on quality of life, causing social and physical disability, employment problems, productivity loss, feeling of stigmatization, depression, and other psychological problems. In RA patients, concomitant MTX therapy was associated with a reduced incidence of AAA formation as compared to adalimumab monotherapy (1 versus 12 ). Interestingly, restoration of clinical response after the increase of dosing frequency in patients who were previously non-responders was associated with the disappearance of AAA. Depression and organic factors appear to play a key role in this relation. Eighty patients with moderate to severe psoriasis and 80 healthy controls were included.
Joint disease is associated with psoriasis in a significant proportion of patients (reported in one study to be 13. Tools such as the Dermatology Life Quality Index may be helpful. Nail psoriasis results from psoriatic involvement of the nail bed or nail matrix. Patients with nail psoriasis may experience associated pain, psychological distress, and functional impairments resulting in interference with activities of daily living 17. Adalimumab for treatment of moderate to severe chronic plaque psoriasis of the hands and feet: efficacy and safety results from REACH, a randomized, placebo-controlled, double-blind trial. Severe psoriasis was also associated with a four-fold increased incident risk of end-stage renal disease (Table 1). Patients with both CD and psoriasis may benefit from therapy with the anti-TNF agents adalimumab or infliximab; these two agents are approved by the US Food and Drug Administration (FDA) for both conditions. After adjustment for CV risk factors, severe psoriasis was associated with a 53 increased risk for MACE (Table 1) as well as a 6. A common genetic background as well as several acquired risk factors links psoriasis to comorbidities. Moderate to severe psoriasis is defined if the body surface involvement is 10. Patients with psoriasis, like those with other major medical disorders, have a worse quality of life, reduced life expectancy as well as employment and income (5). Colonoscopic image of a large ulcer and inflammation of the descending colon in a 12-year-old boy with Crohn disease. A risk-stratification model based on C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), which are significantly associated with complications of Crohn disease, could reduce the use of computed tomography (CT) scans in patients reporting to the emergency room by 43, while missing only 0. Psychosocial issues (eg, depression, anxiety, and coping difficulty); pediatric patients may also experience psychological issues regarding quality of life and body image 5, 6. Medications used in the treatment of Crohn disease include the following:. Compared to patients with mild psoriasis, patients with severe psoriasis have 1.8 times greater odds to be unemployed after adjusting for age and gender (Adjusted OR 1. The National Psoriasis Foundation (NPF) conducts semiannual surveys and collects information regarding comorbid conditions, medication use, treatment patterns, impact on quality of life, and disease burden. Furthermore, the NPF survey allows for assessment of psoriasis severity based on self-reported body surface area involvement, which represents a direct assessment of psoriasis severity. Original image ().
Quality Of Life In Patients With Psoriasis
Depression and organic factors appear to play a key role in this relationship. Multivariate logistic regression analysis showed that the involvement of these specific areas may be independent risk factors for sexual dysfunction in patients with moderate to severe psoriasis. Conclusions. This is the first study identifying body areas other than genitals as potentially related to sexual dysfunction in psoriasis patients.