Pustular psoriasis of the nail apparatus is characterized by the formation of sterile pustules, starting on one or two fingers or less often on the toes, and spontaneous improvement has rarely been observed. The nail matrix is responsible for the formation of the nail plate and is located primarily beneath the proximal nail fold, with the distal one-third visible as the lunula (picture 2 and figure 1). The site of psoriasis in the nail apparatus leads to specific effects on nail formation and determines the clinical manifestations. Alopecia areata Nail pitting, trachyonychia (linear ridging), onychorrhexis (longitudinal fissuring), and other nail abnormalities may occur in patients with alopecia areata, a form of hair loss characterized by nonscarring patchy hair loss on the scalp or other areas of the body (picture 12A-B). Long-term study of infliximab in Japanese patients with plaque psoriasis, psoriatic arthritis, pustular psoriasis and psoriatic erythroderma. Psoriatic nails resemble onychomycosis and often both conditions arise simultaneously. At a cellular level, all psoriasis is basically pustular with foci of neutrophils forming microabscesses. The specific site of the attack determines the effects of psoriasis on the nail unit.
It results from maturation and keratinization of the nail matrix epithelium and is firmly attached to the nail bed, which partially contributes to its formation. The underpart of the nail is formed from the stratum germinativum of the epidermis, the free surface from the stratum lucidum, and the thin cuticular fold overlapping the lunula representing the stratum corneum. Brittle nails common condition, e.g. in middle-aged women, characterized by lamellar splits, associated with repeated immersion in detergent water. The formation of almost all components of the skin (for example, hair texture and colour and skin pigmentation and thickness) is under genetic control. As an inflammatory disorder, psoriasis is characterized by nests of neutrophil leukocytes in the epidermis called microabscesses. Some organisms, such as staphylococci and streptococci, produce a pustular infection (impetigo, boils) in which the main features are acute inflammation and the accumulation of large numbers of white blood cells as pus.
Clinically, it is characterized by groups of tiny sterile pustules that develop on a background of bright red skin. Although not unique in this regard, LP is remarkable because it has a tendency to involve the entire integument producing specific clinical and histologic lesions of skin, mucous membranes, hair follicles, and the nail apparatus. Post-inflammatory hyperpigmentation develops over time, and there is risk of ulcer formation after minor trauma to the malleoli. Psoriatic onycholysis this case is very typical 9.1 Onycholysis 43 Fig. 77 14 Pustular Psoriasis. 1 Congenital Anonychia/Micronychia 5 Epidermolysis bullosae Anonychia is a feature of junctional and dermolytic epidermolysis bullosa, where it is a sequela of bullae formation. (PC) are a group of genetic disorders characterized by nail thickness. Nail psoriasis has a substantial psychosocial impact. It is a reproducible, numeric, objective tool to evaluate the severity of nail matrix psoriasis and nail bed psoriasis by area of involvement in the nail unit. Clinical diagnosis of active psoriatic arthritis and pustular psoriasis of the nail apparatus including acrodermatitis continua of Hallopeau.
Psoriasis is a common skin disorder characterized by focal formation of raised plaques that constantly shed scales derived from excessive growth of skin epithelial cells. Types of psoriasis that In a developing psoriatic plaque, endothelial cells swell and become activated, showing prominent Golgi apparatus and Weibel-Palade bodies. Acne Vulgaris A chronic disorder of the pilosebaceous apparatus associated with an increase in sebum secretion. It is characterized by open comedones (blackheads), closed comedones (whiteheads), and pustular nodules. In infants it is known as infantile eczema. Herpes any inflammatory skin disease caused by a herpesvirus and characterized by the formation of clusters of small vesicles.