Hindawi Publishing Corporation. Topical therapies available for mild-to-moderate psoriasis involve a great number of different agents, including 3, 7, 8 (i)emollients;(ii)tars;(iii)dithranol;(iv)topical retinoids (Tazarotene);(v)calcineurin inhibitors (pimecrolimus and tacrolimus);(vi)keratolytics (salicylic acid, urea);(vii)topical vitamin D analogues (calcitriol, tacalcitol, and calcipotriol);(viii)topical corticosteroids. Th17 cells produce IL-22, which have potent keratinocyte proliferative ability. Treatment options for moderate to severe psoriasis include topical and systemic medications, phototherapy, and excimer laser, Combination therapies are often more effective than one treatment alone. The condition may also be triggered by certain psoriasis treatments, and other medications such as corticosteroids or synthetic antimalarial drugs. Many creams, ointments, lotions, and pills are available to treat psoriasis. Psoriasis is a long-lasting autoimmune disease characterized by patches of abnormal skin. Interleukin-23 is known to induce the production of interleukin-17 and interleukin-22. Another topical therapy used to treat psoriasis is a form of balneotherapy, which involves daily baths in the Dead Sea. Professional guidelines regard biologics as third-line treatment for plaque psoriasis following inadequate response to topical treatment, phototherapy, and non-biologic systemic treatments.
Psoriatic nail disease occurs in about 50 of patients with psoriasis. Topical treatments: topical corticosteroids, salicylic acid, calcipotriol, or tazarotene used alone or in combination can be considered. Eligible patients with psoriasis vulgaris (PV) were enrolled into a randomized comparison in which all subjects received topical sequential therapy and PSORI-CM01 or placebo for 12 weeks. However, no evidence of CHM for reducing the relapse of PV is available. Topical sequential therapy with a combination of calcipotriol and calcipotriol betamethasone was significantly superior to the use of each therapy alone from a pharmacoeconomic standpoint according to the Guidelines for the Treatment of PV 8. Treatment of Psoriasis with Topical Agents InTechOpen, Published on: 2013-04-17. Summary of topical medications used in psoriasis treatment. Moreover, 17-55 of patients experience remissions of varying lengths. The general observation of the psoriasis guideline therapy reveals that the basic decisions are based on psoriasis intensity and its form of clinical manifestation.