We compared serum levels of vitamin D of 20 psoriasis patients and 20 controls. Efficacy of Vitamin D3 for the Treatment of Psoriatic Patients With Vitamin D Deficiency and Insufficiency. Psoriasis vulgaris patient with vitamin D insufficiency or deficiency. Psoriasis vulgaris (PV) is a common chronic autoimmune disease manifesting as thick scaly red plaques on the skin. Patients with psoriasis are more prone to other autoimmune diseases, cardiovascular disease, diabetes, obesity, and metabolic syndrome. Epidemiologic data have shown that vitamin D deficiency may be a risk for development of other autoimmune diseases, including rheumatoid arthritis (RA), multiple sclerosis (MS), systemic lupus erythematosus (SLE), and Crohn’s disease (CD).
Figure 1 shows the vitamin D3 pathway in human skin. A pilot study assessing the role of 25 hydroxy vitamin D levels in patients with vitiligo vulgaris. Nine patients with psoriasis vulgaris had no clinical signs of joint inflammation (PsV) and twelve were diagnosed with psoriatic arthritis (PsA). However deficient 25(OH)D level may be linked to autoimmune disorders in patients. Vitamin D analogues are effective topical therapies for cutaneous autoimmune conditions including psoriasis and vitiligo. Silverberg J, Silverberg A (2010) A pilot study assessing the role of 25 hydroxyvitamin D levels in patients with vitiligo vulgaris.
All patients showed deficient vitamin D levels (11.1 5.8 ng/ml). Autoimmune bullous disease Pemphigus vulgaris Vitamin-D IL-17 TGF-b. Autoimmunity has been associated with vitamin D deficiency and resistance, with gene polymorphisms related to vitamin D metabolism frequently described in affected patients. Nine patients with psoriasis and 16 patients with vitiligo received vitamin D3 35,000 IU once daily for six months in association with a low-calcium diet (avoiding dairy products and calcium-enriched foods like oat, rice or soya milk ) and hydration (minimum 2. A pilot study assessing the role of 25 hydroxy vitamin D levels in patients with vitiligo vulgaris. Patients with psoriatic arthritis (PsA) have a high prevalence of vitamin D insufficiency, with no evidence of seasonal or geographic variation or association between vitamin D levels and disease activity, according to a study published online July 11 in Arthritis Care & Research., from the Toronto Western Hospital, and colleagues investigated the prevalence of vitamin D deficiency and insufficiency in 302 patients with PsA, its seasonal and geographic variation, and the possible correlation with disease activity.
Vitamin D And Skin Diseases: A Review Wadhwa B, Relhan V, Goel K, Kochhar Am, Garg Vk
Vitamin D deficiency is a major unrecognized health problem. There are two commercial sources of natural vitamin D3: fish liver oil and an oil extracted from wool. This year, the British Medical Journal published a double-blind controlled trial of 100,000 IU vitamin D3 given orally to over 2,000 elderly patients once every four months, for five years. Kozuka T et al: An open study of vitamin D3 treatment in psoriasis vulgaris. Are Solarc devices approved by the government for Vitamin-D deficiency? One wonders how many psoriasis patients were simply Vitamin-D deficient before getting the disease? To learn more, there are many medical abstracts on this subject at: PubMed Can human evolution explain today’s widespread occurrence of Vitamin-D deficiency among people living at high latitudes? Considering/assuming that primates have been evolving for some 85 million years, (and humans for a couple of million years), in an environment awash with natural ultraviolet light from the sun, it is reasonable that we have developed ways to use UV beneficially (Vitamin-D production), and a means to prevent overexposure (tanning). 76 359 WALTERS I, (1999) Suberythematogenic narrow-band UVB is markedly more effective than conventional UVB in treatment of psoriasis vulgaris. Prevalence of atopic disorders in Vit D deficient patients when compared withVit D sufficient patients showed an increased risk of atopic dermatitis among those patients who were Vit D deficient. Vitamin D refers to a group of fat-soluble secosteroids responsible for enhancing intestinal absorption of calcium, iron, magnesium, phosphate, and zinc. A diet deficient in vitamin D in conjunction with inadequate sun exposure causes osteomalacia (or rickets when it occurs in children), which is a softening of the bones. This dose should be increased to 4,000 IU/day in some patients with very low vitamin D status or in case of comorbid conditions. Other uses include plaque-type psoriasis, actinic keratosis, lupus vulgaris, squamous cell carcinomas, vitiligo, scleroderma, myelodysplastic syndrome, periodontal disease, hypertension, hyperlipidemia, cardiovascular disease, obesity, and diabetes. Taking calcifediol, cholecalciferol (vitamin D3), calcitriol, or alfacalcidol orally prevents corticosteroid-induced osteopenia and osteoporosis (7555, 83933). The majority of patients with myalgia were found to be vitamin D deficient with 25-OH vitamin D levels less than 30 nmol/L before starting a supplement (16829).