Last updated: October 19, 2012. The purpose of this study is to compare the efficacy and safety of CNTO 1275 to etanercept in patients with moderate to severe plaque psoriasis. This is a test of how bad a person’s psoriasis is. Li S, Dooley LT, Goldstein NH, Menter A; ACCEPT Study Group. Clinical trials that have investigated the role of biologics in psoriasis therapy are reviewed in Table 2a and and2b2b. Epub 2010 Mar 19. Continued sub-clinical streptococcal infection might be responsible for chronic plaque psoriasis. Though the trial concluded at 48 weeks, patients in the azithromycin-arm were followed for another year to observe any relapse.
Apremilast offers an oral treatment option for patients with psoriasis. Research from JAMA Dermatology Association of Pediatric Psoriasis Severity With Excess and Central Adiposity An International Cross-Sectional Study. Children were enrolled from 9 countries between June 19, 2009, and December 2, 2011. Find a clinical trial for Psoriasis and sign up to take part. Find out more about clinical studies and search for a clinical trial in your area. Registered number: 06553923 Registered office: Rawdon House, Green Lane, Yeadon, Leeds LS19 7BY Patient is a UK registered trade mark.
Secukinumab, A Human Anti-interleukin-17a Monoclonal Antibody, In Patients With Psoriatic Arthritis (future 2): A Randomised, Double-blind, Placebo
In this paper, the good SPC endpoint was applied to efalizumab clinical trial data as described in the following section (Table 1). Received 3 May 2013; Accepted 19 July 2013. A study performed in Caucasian patients with early-onset psoriasis showed a strong association with TNF polymorphisms (rs1800629 and rs361525) (Table 1) 19. With psoriasis affecting millions in the US, new data adds evidence for the links between the condition and a susceptibility to cardiac disease. The patients were followed until they suffered an abdominal aortic aneurysm, moved out of the country, died or the study ended. Please note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. June 19, 2014. After two months on tofacitinib at 10 mg daily, the patient’s psoriasis showed some improvement, and the man had grown scalp and facial hair the first hair he’d grown there in seven years. King has submitted a proposal for a clinical trial involving a cream form of tofacitinib as a treatment for alopecia areata. Taking a vacation from diabetes: Teens take ‘artificial pancreas’ for a test run. Here we evaluate tildrakizumab, a monoclonal antibody that targets the IL-23p19 subunit, in a three-part, randomized, placebo-controlled, sequential, rising multiple-dose phase I study in patients with moderate-to-severe psoriasis to provide clinical proof that specific targeting of IL-23p19 results in symptomatic improvement of disease severity in human subjects. Identification of IL-23p19-producing cells in psoriatic lesions. A patient-initiated DMARD self-monitoring service for people with rheumatoid or psoriatic arthritis on methotrexate: a randomised controlled trial.
Apremilast, An Oral Phosphodiesterase 4 (pde4) Inhibitor, In Patients With Moderate To Severe Plaque Psoriasis: Results Of A Phase Iii, Randomized, Controlled Trial (efficacy And Safety Trial Evaluating The Effects Of Apremilast In Psoriasis 1)
We know that some people with psoriasis will develop psoriatic arthritis, but is not fully understood why some people do and some do not. The study requires patients to take one of two treatments (after randomisation) for their skin psoriasis. Open label trial of alefacept in palmoplantar pustular psoriasis.