Other Immunosuppressive Drugs and Agents -Psoriasis patients receiving other immunosuppressive agents or radiation therapy (including PUVA and UVB) should not receive concurrent cyclosporine because of the possibility of excessive immunosuppression. If a patient who is receiving exceptionally high doses of Sandimmune (Cyclosporine Oral Solution USP) is converted to Cyclosporine Oral Solution USP MODIFIED, particular caution should be exercised. Psoriasis patients previously treated with PUVA and to a lesser extent, methotrexate or other immunosuppressive agents, UVB, coal tar, or radiation therapy, are at an increased risk of developing skin malignancies when taking Cyclosporine Oral Solution USP MODIFIED. Psoriasis patients who are treated with Cyclosporine Oral Solution USP MODIFIED should not receive concomitant PUVA or UVB therapy, methotrexate or other immunosuppressive agents, coal tar or radiation therapy. Medications that reduce the activity of an immune factor called TNF can help patients with severe psoriasis.
Cyclosporine is an immunosuppressive drug that was first used to help prevent rejection in organ transplant patients. Monitor cyclosporine blood concentrations in transplant and rheumatoid arthritis (RA) patients to avoid toxicity due to high concentrations. Avoid in psoriasis patients receiving other immunosuppressive agents or radiation therapy (including PUVA and UVB). The concept that many patients with psoriasis in the United States do not receive sufficient treatment to control the disease is suggested by an analysis of surveys performed by the National Psoriasis Foundation between 2003 and 2011 2. The primary care clinician is not familiar with the treatment modality recommended such as PUVA, phototherapy, or immunosuppressive medications. In choosing UV therapy, consideration must be given to the potential for UV radiation to accelerate photodamage and increase the risk of cutaneous malignancy.
Prevention and treatment of graft vs. host disease in bone marrow transplant patients. Consequently, there is a need to evaluate the risk of malignancies in psoriasis patients receiving cyclosporine and to identify the possible role of other risk factors in the development of malignancy. MTX, methotrexate; ioniz. rad., ionizing radiation; immuno., immunosuppressant w/o cyclosporine; fumaric a., fumaric acid. Over half of patients with psoriasis have abnormal changes in their nails, which may appear before other skin symptoms.
Treating Psoriasis: Systemic Medications: Cyclosporine
Azathioprine (AZA), also known by its brand name Imuran, is an immunosuppressive drug used in organ transplantation and autoimmune diseases and belongs to the chemical class of purine analogues. The British National Eczema Society lists it as a third-line treatment for severe to moderate cases of these skin diseases. Hair loss is often seen in transplant patients receiving the drug, but rarely occurs under other indications. Because azathioprine suppresses the bone marrow, patients can develop anaemia and will be more susceptible to infection; regular monitoring of the blood count is recommended during treatment. Outcome of radiation therapy for renal transplant rejection refractory to chemical immunosuppression. Ciclosporin (Neoral; Novartis) is a potent immunosuppressant used worldwide to treat psoriasis. If you are receiving immunosuppressant medicine, you may not develop disease immunity from the vaccination.Taking a live vaccine may cause you to develop the illness it was supposed to prevent.