Psoriasis is a systemic, immune-mediated disorder, characterized by inflammatory skin and joint manifestations. Metabolic diseases such as obesity and diabetes have overlapping genetic predispositions with psoriasis. Both conditions are likely to also interact at a functional level because obesity and the up-regulation of pro-inflammatory mediators in psoriasis appear to influence adipocyte homoeostasis, inducing non-professional immune functions. Psoriasis is an immune-mediated, genetic disease manifesting in the skin or joints or both. A diverse team of clinicians with a range of expertise is often needed to treat the disease. Nowadays, Ps is considered an immune-mediated skin disease, and PsA regarded as a seronegative (rheumatoid factor negative) arthritis.
Psoriasis is a common chronic, recurrent, immune mediated disease of the skin and joints. There are several clinical cutaneous manifestations of psoriasis but most commonly the disease presents as chronic, symmetrical, erythematous, scaling papules and plaques. The molecular genetic basis of psoriasis is complex with evidence that multiple genes are involved. Bimodality in age of onset of psoriasis, in both patients and their relatives. Psoriasis is a long-lasting autoimmune disease characterized by patches of abnormal skin. Psoriasis is generally thought to be a genetic disease which is triggered by environmental factors. In twin studies, identical twins are three times more likely to both be affected compared to non-identical twins; this suggests that genetic factors predispose to psoriasis. The underlying mechanism involves the immune system reacting to skin cells. Psoriasis is a complex immune-mediated disease that can manifest in the skin and joints. The condition manifests itself in the skin, joints, or both, and exhibits associated comorbidities that increase risk for early death, including metabolic syndrome, cardiovascular disease, psoriatic arthritis, depression, anxiety, nonalcoholic fatty liver disease, Crohn’s disease, and lymphoma. Family studies have shown a genetic predisposition for the disease, with the literature illustrating certain susceptibility alleles in immune-related genes.
Eczema, or dermatitis as it is sometimes called, is a group of skin conditions which can affect all age groups. Both of these conditions are the result of the body’s immune system over reacting to an irritation to the skin. There is no cure, but many different treatments, both topical (on the skin) and systemic (throughout the body), can clear psoriasis for periods of time. In severe cases, psoriatic arthritis can be disabling and cause irreversible damage to joints. Learn about the different types of psoriasis, whether or not psoriasis is contagious and treatment options. Psoriasis is an immune-mediated, genetic disease manifesting in the skin and/or the joints. There is no medically recognized cure, but many different psoriasis treatments, both topical (on the skin) and systemic (throughout the body) can clear psoriasis for periods of time.
Psoriasis: Epidemiology, Clinical Features, And Quality Of Life