Psoriasis is a disease with considerable heterogeneity in clinical presentation. This is the first study using two-dimensional gel electrophoresis to compare global protein expression patterns in lesional and non-lesional skin from subjects with acute guttate psoriasis associated with streptococcal throat infection and chronic plaque psoriasis. Altered immune function antedates disease presentation across autoimmune diseases. Psoriasis is a common chronic, recurrent, immune mediated disease of the skin and joints. This paper reviews the epidemiology and clinical features of psoriasis and its impact of patients’ quality of life. Although psoriasis occurs worldwide, its prevalence varies considerably. The difficulty of confirming psoriasis susceptibility loci may relate, in part, to heterogeneity among different populations.
The heterogeneity of clinical manifestations (eg, oligoarthritis and polyarthritis, and spinal, ligamentous and tendon involvement) complicates assessment of PsA outcomes and broadens its impact on daily life. 7 Given the heterogeneity of the clinical manifestations, measuring disease activity and disease impact can be difficult. Of importance, many other domains (enthesitis, dactylitis, spine and nails) specific to PsA are now being assessed to supplement the 2006 PsA core set in a considerable proportion of PsA RCTs, but the selection of additional domains is heterogeneous across trials. Psoriatic arthritis (PsA) is a heterogeneous disease with diverse clinical and radiographic manifestations. Nonetheless, patients often differ considerably from one another in the type of their clinical manifestations, including whether or not they exhibit dactylitis, enthesitis, asymmetric or symmetric sacroiliitis, or joint deformity, but also in the presence and type of joint damage on plain radiography. Enthesitis may be a prominent clinical feature at presentation in up to 38 of PsA patients 15. The cardinal clinical features of PRP are hyperkeratotic follicular papules, orange-red scaling plaques, and.
Keywords: Disease Activity, Enthesitis, psoriatic arthritis and registries. Background/Purpose: Psoriatic arthritis (PsA) exhibits considerable heterogeneity in its presentation and course, which contributes to the complexity of diagnosis and assessment. Neurologic symptoms and signs such as seizures and movement disorders (eg, dystonia, chorea) may accompany ataxia. This feature likely contributes to significant overlap seen in the clinical presentation. Some phenotypes (dominant ataxias) show considerable genetic heterogeneity. Systemic Lupus Erythematosus (SLE) is an autoimmune disorder characterized by excessive production of a variety of autoantibodies and a wide range of clinical manifestations. Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease with considerable heterogeneity in clinical manifestations and disease course 1.
Systematic Literature Review Of Domains Assessed In Psoriatic Arthritis To Inform The Update Of The Psoriatic Arthritis Core Domain Set
Secukinumab as a Treatment Option in PsA. The concept of psoriatic arthritis (PsA) has evolved considerably over the past decade from that of a relatively obscure, mild joint disease to that of a prevalent, complex, potentially disabling musculoskeletal syndrome. The multifaceted nature of PsA may be observed in the heterogeneous clinical presentations elegantly described by Moll and Wright. Keywords: psoriatic arthritis, disease-modifying antirheumatic drugs, biologics. 96); however, there was evidence of considerable heterogeneity between trials. The clinical heterogeneity along with the varying extent of severity and activity can pose significant challenges to treatment. There are significant genetic associations common to psoriasis and PsA, some of which overlap with other autoimmune conditions 2. The diagnosis of PsA is clinical as there are no pathognomonic, serological, imaging or other diagnostic tests. One small study compared the use of early IA steroid injection vs conservative management with NSAIDs in early PsA patients presenting with oligoarticular disease. In addition, there is considerable heterogeneity between patients, in terms of skin versus muscle inflammation. Risk of Serious Infection With Biologic and Systemic Treatment of Psoriasis Results From the Psoriasis Longitudinal Assessment and Registry (PSOLAR) JAMA DERMATOLOGY Kalb, R. Systemic sclerosis is an autoimmune disease characterized by inflammation and fibrosis of the skin and internal organs. This clinical heterogeneity has important implications in disease recognition, treatment, and prognosis. In these circumstances, a correct diagnosis of psoriasis may not be so easy. Psoriasis is a long-lasting autoimmune disease characterized by patches of abnormal skin. Diagnosis is typically based on the signs and symptoms. The classification of psoriasis as an autoimmune disease has sparked considerable debate.
Clinical Characteristics And Disease Activity In Psoriatic Arthritis Patients With Dactylitis Or Enthesitis: Results From Corrona Registry
Additionally, a considerable number of patients do not respond well to conventional therapy. Recently, asthma has been found to be a heterogeneous disease with different phenotypes. SB020, sterna biologicals’ drug candidate for the treatment of psoriasis, represents a novel therapeutic approach by directly inhibiting Th1 cell activation and subsequent inflammatory mechanisms.