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Plasmacytoid preden- dritic cells initiate psoriasis through interferon-alpha production

IFN- production in developing psoriatic lesions is mediated by PDCs. Interferon alpha-inducible protein 27 (IFI27) is upregulated in psoriatic skin and certain epithelial cancers. Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production. Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production. We show that plasmacytoid predendritic cells (PDCs), the natural interferon (IFN)-alpha-producing cells, infiltrate the skin of psoriatic patients and become activated to produce IFN-alpha early during disease formation. Individual plasmacytoid dendritic cells are major contributors to the production of multiple innate cytokines in an organ-specific manner during viral infection.

Plasmacytoid preden- dritic cells initiate psoriasis through interferon-alpha production 2Plasmacytoid Predendritic Cells Initiating Psoriasis. Title: Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production. Authors: Nestle FO, et al. F1000Prime Recommended Article: Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production. Original article. Nestle FO et al. (2005) Plasmacytoid predendritic cells initiate psoriasis through interferon- alpha production. J Exp Med 202: 135143 PubMed.

Human plasmacytoid dendritic cells (pDCs) are found in skin lesions in a wide variety of diseases. Plasmacytoid dendritic cells (pDC) are present in inflammatory skin lesions, in particular, in psoriasis. In contrast, interferon alpha production, surface molecule expression, and T-cell stimulatory capacity were not significantly modulated by C3a or C5a.

Plasmocytoid Predendritic Cell (pdc) Initiate Psoriasis Through Interferon-alpha

IRF-5 was also shown to be critical for normal pDC activation, because although pDC from mice lacking IRF-5 showed normal IFN- production in response to CpG, the production of IL-6 and IL-12 p40 was severely diminished in pDC and all other cell types examined (cDC and macrophages). Preferentially expressed by plasmacytoid dendritic cells, type I IFNs are induced by viral infection and in common skin wounds. 1-3 of the population, is a chronic inflammatory disease characterized by the production of cytokines mediated by T-lymphocytes that boost hyperproliferation and abnormal differentiation of keratinocytes 1. Nestle FO, Conrad C, Tun-Kyi A, Homey B, Gombert M, Boyman O, et al: Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production. The natural IFN-a-producing cells, termed plasmacytoid dendritic cells, have been identified in early lesions of psoriasis, and inhibition of IFN-a production can prevent the development of psoriatic lesions in mice grafted with human skin21. Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production. Plasmacytoid dendritic cells (pDCs) play not only a central role in the antiviral immune response in innate host defense, but also a pathogenic role in the development of the autoimmune process by their ability to produce robust amounts of type I interferons (IFNs), through sensing nucleic acids by toll-like receptor (TLR) 7 and 9. Thus, control of dysregulated pDC activation and type I IFN production provide an alternative treatment strategy for autoimmune diseases in which type I IFNs are elevated, such as systemic lupus erythematosus (SLE). Gilliet M: Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production. Human plasmacytoid predendritic cells (pDCs) can be activated during microbial infection through Toll-like receptor engagement. Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production.

Il-4 And Il-13 Alter Plasmacytoid Dendritic Cell Responsiveness To Cpg Dna And Herpes Simplex Virus-1

Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production.