We report 22 patients treated with clofazimine for chronic graft-versus-host disease (cGVHD). The mechanism by which clofazimine induces a response is unknown, but might be secondary to suppression of alloreactive T-cell function in cGVHD target organs. 13 Furthermore, it has demonstrated efficacy in the treatment of immune-mediated skin disease such as cutaneous discoid and annular lupus erythematosis,14 15 pyoderma gangrenosum,16-19 and pustular psoriasis.20 The mechanism of clofazimine action in these conditions is unknown, but is thought to reflect functional inhibition of pathogenic T lymphocytes. Br J Dermatol 1978;99:303. Chuaprapaisilp, T.; Piamphongsant, T.: Treatment of pustular psoriasis with clofazimine. Br. J. Derm. 99: 303305 (1978). Downloaded by:. Chuaprapaisilp T, Piamphongsant T: Treatment of pustular psoriasis with clofazimine. Br J. Dermatol 1978;99:303305.
Chang (4) observed the antibacterial activity of clofazimine against Mycobacterium lepraemurium at about the same time as its anti-M. Chuaprapaisilp, T.; Piamphongsant, T.Treatment of Pustular Psoriasis with Clofazimine Br. J. Dermatol. 1978, 99, 303 305. Interestingly, clofazimine, a drug that treats pustular psoriasis in humans (Chuaprapaisilp and Piamphongsant, 1978; Nair and Shereef, 1991), has been shown to block Kv1. Chuaprapaisilp T, Piamphongsant T. Treatment of pustular psoriasis with clofazimine.
Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytesJ. 36Chuaprapaisilp T,Piamphongsant T.Treatment of pustular psoriasis with clofazimineJ.Br J Dermatol,1978,99(3):303-305. Piamphongsant T. Dapsone for the treatment of bullous pemphigoid. Wolff K. Subcorneal pustular dermatosis is not pustular psoriasis. Van Zyl J, Basson K, Kriegler A, van der Walt B. Mechanisms by which clofazimine and dapsone inhibit the myeloperoxidase system. Because the newer methods of treatment are good, it does not follow that the old ones were bad: for if our honorable and worshipful ancestors had not recovered from their ailments, you and I would not be here today.