Skip to content

Patients psoriasis to be treated with Excimer laser phototherapy based on conventional dosing guidelines

Psychosocial aspects Psoriasis can be a frustrating disease for the patient and the provider. Topical therapy may provide symptomatic relief, minimize required doses of systemic medications, and may even be psychologically cathartic for some patients. Phototherapy (eg, excimer laser) and systemic agents are additional treatment options for patients who cannot achieve sufficient improvement with topical agents 10. Guidelines for the treatment of children based upon the available evidence have been published 17. The authors concluded that the excimer laser appears to be safe and effective for psoriasis, and has an advantage over conventional photo-chemotherapy in that it requires fewer visits and targets only the affective areas of skin, sparing the surrounding uninvolved skin. Two plaques were selected on each patient, and half of each plaque was treated with a single excimer laser dose, whereas the other half (control) was left untreated. THERAPY Efficacy of the 308-nm excimer laser for treatment of psoriasis: Results of a multicenter study Steven R. Subsequent doses were based on the response to treatment. Of the patients who met the protocol requirements of 10 treatments or clearing, 72 (66/92) achieved at least 75 clearing in an average of 6. It requires fewer patient visits than conventional phototherapy, and, unlike those treatments, the laser targets only the affected areas of the skin, sparing the surrounding uninvolved skin.

Patients psoriasis to be treated with Excimer laser phototherapy based on conventional dosing guidelines 2Today, there is another option for treating psoriasis: excimer lasers, which deliver ultraviolet light to localized areas of the skin. Targeted laser therapy is similar in effectiveness to traditional light therapy, but it works in fewer sessions with stronger doses of light that can reach deeper into the affected skin. With excimer laser therapy, patients usually have two treatments lasting 15-30 minutes each week for three or more weeks, with at least a 48-hour break between treatments. Your doctor will determine your dose of laser light based on the thickness of your psoriasis plaques and your skin color (a lower dose is used on lighter skin). This chapter will discuss the entire spectrum of phototherapy, including narrowband UVB photo-therapy, broadband UVB phototherapy, PUVA, targeted excimer laser phototherapy, and combination treatments. Bnis et al. treated 10 psoriatic patients with excimer laser and 6 patients with NB-UVB.

Medicated foams and scalp solutions are available to treat psoriasis patches on the scalp. Calcipotriene (Dovonex) is a prescription cream or solution containing a vitamin D analogue that may be used alone to treat mild to moderate psoriasis or in combination with other topical medications or phototherapy. Controlled doses of UVB light from an artificial light source may improve mild to moderate psoriasis symptoms. Excimer laser therapy requires fewer sessions than does traditional phototherapy because more powerful UVB light is used. Within each plaque, 8 doses based on multiples of a predetermined minimal erythema dose (MED) were tested in distinct sites. We’ll send instructions on how to reset your password to the email address we have on record. Asp?2016/82/1/1/172902 Introduction Targeted phototherapy (also called concentrated phototherapy, focused phototherapy and microphototherapy) is a new form of phototherapy which seeks to overcome some of the disadvantages with conventional phototherapy. Higher doses of energy can be delivered selectively to the lesions thereby enhancing efficacy and achieving faster response. A large study of 140 patients with vitiligo treated by excimer laser showed excellent results in ultraviolet-sensitive areas while ultraviolet-resistant areas such as acral lesions and lesions on joint areas responded poorly.

Laser Treatments For Psoriasis: Are They Effective?

Almost all patients with Psoriasis are candidates for XTRAC Laser Therapy.. at some point. Treating may include lifestyle changes, nutrition, and medication. They’re usually the first line of treatment for patients with mild to moderate psoriasis. These low-dose steroid treatments work to control the excessive production of skin cells, soothe skin, and help symptoms. Excimer Laser. Lasers can target concentrated beams of UVB light on psoriatic patches without affecting surrounding skin. Targeted UVB laser phototherapy is one of the most cutting-edge advances in phototherapy. The 308 nm excimer laser can be used to treat plaque psoriasis,4 vitiligo4,5 and early-stage mycosis fungoides. 6 Moreover, excimer laser has been reported to be more effective than conventional NB-UVB therapy in treating psoriasis. All studies determined the initial treatment dose using either the minimal erythema dose (MED) or induration. Conclusion: The 308 nm excimer laser is an effective therapy for psoriasis regardless of the method used to determine initial dosage, dose fluency, or number of treatments. Based on our reviewed studies, there is no consensus for a single excimer laser therapy protocol and as a result, patient preferences should continue to be an important consid- eration for phototherapy regimen planning. This review characterizes the different elements in 308 nm excimer la- ser phototherapy protocols in order to facilitate evidence-based management of localized psoriasis in the clinical setting. In 1978, came the broadband UVB for the treatment of psoriasis but could not achieve popularity for the lack of efficacy. A potential advance in UVB-based phototherapy has been the introduction of fluorescent bulbs (Phillips model TL-01) that deliver UVB in the range of 310-315 nm, with a peak at 312 nm. Thus, patients with vitiligo should be treated on a 48-h dosing schedule to allow adequate DNA repair to take place, and 24-h dosing schedules should be avoided. Phototherapy is the use of ultraviolet irradiation with or without exogenous photosensitizer. It can be administered as photochemotherapy, Broadband UVB and narrowband UVB therapy, Excimer laser, UVA1 phototherapy and photodyanamic therapy. Because PUVA therapy is based on photosensitizing effects, it is contraindicated in patients with photosensitive diseases such as systemic lupus erythematosus and porphyria cutanea tarda. High dose means using a treatment schedule aimed at staying close to or above the erythema threshold of the patient throughout the course of treatment.

Psoriasis Treatments And Drugs

Topical agents, Excimer Laser Treatments, Conventional broad band UVB, PUVA, New Biologic Agents, Soriatane, Methotrexate, Cyclosporine. Before light treatment, some patients apply mineral oil to their psoriatic plaques. Scalp disease is treated by a specifically designed light-based hair comb. A predetermined starting dose of light is administered, with subsequent increases of approximately 10-15 for each treatment.