Purpose The purpose of this study is to evaluate the efficacy, safety, and tolerability of guselkumab (CNTO 1959) in the treatment of participants with moderate to severe plaque-type psoriasis. Treatment groups to be analyzed: Guselkumab vs Adalimumab. Treatment of Participants With Moderate to Severe Plaque-Type Psoriasis With Randomized Withdrawal and Retreatment (VOYAGE 2). Drug Information available for: Adalimumab. Purpose The two objectives of this study were to evaluate long-term efficacy and safety of adalimumab treatment in participants who had moderate to severe chronic plaque psoriasis and to evaluate the effectiveness of adalimumab retreatment in participants who had therapeutic response to adalimumab and were then withdrawn from adalimumab treatment. Purpose The two objectives of this study were to evaluate long-term efficacy and safety of adalimumab treatment in participants who had moderate to severe chronic plaque psoriasis and to evaluate the effectiveness of adalimumab retreatment in participants who had therapeutic response to adalimumab and were then withdrawn from adalimumab treatment.
Adalimumab for treatment of moderate to severe chronic plaque psoriasis of the hands and feet: efficacy and safety results from REACH, a randomized, placebo-controlled, double-blind trial. Traditional treatments for moderate to severe psoriatic disease include phototherapy, systemic retinoids, methotrexate, and cyclosporine. The results of this phase II study demonstrated the efficacy of adalimumab in the treatment of moderate to severe plaque-type psoriasis. Participants completed the Treatment Satisfaction Questionnaire for Medication.
Comparative effectiveness of commonly used systemic treatments or phototherapy for moderate to severe plaque psoriasis in the clinical practice setting. To compare the effectiveness of biologic systemic therapy, nonbiologic systemic therapy, and phototherapy for treatment of psoriasis. Ten outpatient dermatology sites across the United States participating in the Dermatology Clinical Effectiveness Research Network contributed to the study. The development of several highly effective biologic drugs in the past decade has revolutionized the treatment of moderate-to-severe plaque psoriasis. 1959) in the treatment of participants with moderate to severe plaque-type psoriasis (scaly skin rash).
Adalimumab For Treatment Of Moderate To Severe Chronic Plaque Psoriasis Of The Hands And Feet: Efficacy And Safety Results From Reach, A Randomized
Published evidence questions regulatory guidelines that recommend biologics as second-line therapy for moderate-to-severe plaque psoriasis. However, long-term treatment in patients with moderate to severe psoriasis is limited by the potential for toxic effects on organs, such as renal, hepatic or bone marrow, in addition to teratogenicity and malignancies that are associated with the traditional systemic therapies. Four biologic therapies (adalimumab, efalizumab, etanercept and infliximab) which had been thoroughly revised, are now licensed for the treatment of moderate-to-severe psoriasis. Successful treatment of moderate to severe psoriasis with TNF antagonists improves physical function, as well as social and psychological aspects of psoriasis 10 17. However, patients with psoriasis participating in the REVEAL study were recruited from the United States and Canada. Adalimumab vs Methotrexate for the Treatment of Chronic Plaque Psoriasis. Five-year analysis from the ESPRIT 10-year postmarketing surveillance registry of adalimumab treatment for moderate to severe psoriasis. ESPRIT is an ongoing, 10-year, observational registry, evaluating long-term safety and effectiveness of adalimumab treatment in routine clinical practice for patients with moderate to severe, chronic plaque psoriasis. Two populations were analyzed: the all-treated population received 1 or more adalimumab doses in registry, continuing adalimumab treatment from a current prescription or previous study participation, and included the new-prescription population initiating adalimumab 4 weeks or earlier preregistry entry. Full report on bDMARDs for severe chronic plaque psoriasis (PDF 844KB). To examine the utilisation of the biological disease-modifying anti-rheumatic drugs (bDMARDs) adalimumab, etanercept, infliximab and ustekinumab for the treatment of severe chronic plaque psoriasis on the Pharmaceutical Benefits Scheme (PBS). At its March 2013 meeting in consideration of adalimumab for moderate to severe plaque psoriasis, the PBAC noted there may be a proportion of patients with moderate psoriasis who are receiving PBS subsidised treatment under the restriction for severe psoriasis. Patients with moderate to severe psoriasis (defined as involvement of greater than 5 body surface area or involvement of 5 body surface area affecting sensitive areas or areas that significantly impact daily function (e. Meta-AnalysisWe performed a meta-analysis of randomized controlled trials using the intention-to-treat (ITT) principle to assess the efficacy of etanercept, adalimumab, infliximab, and ustekinumab in treating psoriasis. The primary efficacy outcome was the proportion of participants achieving PASI 75 at month 6 (week 24 28 were acceptable).
Comparative Effectiveness Of Commonly Used Systemic Treatments Or Phototherapy For Moderate To Severe Plaque Psoriasis In The Clinical Practice Set
Clinical trial: Adalimumab in Combination With Topical Treatment (Calcipotriol/Betamethasone) in Subjects With Moderate to Severe Psoriasis and Insufficient Response to Classic Systemic Treatment. Adalimumab in combination with matching vehicle in subjects with moderate to severe chronic plaque psoriasis. Percentage of Participants With a PASI90 Response at Week 16 Compared With Baseline (Week 0). A Phase 2 Trial of Guselkumab versus Adalimumab for Plaque Psoriasis. Little is known about the effect of specific anti interleukin-23 therapy, as compared with established anti tumor necrosis factor therapies, for the treatment of moderate-to-severe plaque psoriasis. Participants: A total of 713 patients with plaque psoriasis receiving systemic monotherapy (ie, methotrexate sodium, adalimumab, etanercept, or ustekinumab) or narrowband UV-B phototherapy. Comparative effectiveness of commonly used systemic treatments or phototherapy for moderate to severe plaque psoriasis in the clinical practice setting.