Psoriasis is a long-lasting autoimmune disease characterized by patches of abnormal skin. There are five main types of psoriasis: plaque, guttate, inverse, pustular, and erythrodermic. Psoriatic erythroderma (erythrodermic psoriasis) involves widespread inflammation and exfoliation of the skin over most of the body surface. Three genes in the PSORS1 locus have a strong association with psoriasis vulgaris: HLA-C variant HLA-Cw6, 31 which encodes a MHC class I protein; CCHCR1, variant WWC, which encodes a coiled protein that is overexpressed in psoriatic epidermis; and CDSN, variant allele 5, which encodes corneodesmosin, a protein which is expressed in the granular and cornified layers of the epidermis and upregulated in psoriasis. Psoriasis is an autoimmune disease that causes raised, red, scaly patches to appear on the skin. While scientists do not know what exactly causes psoriasis, we do know that the immune system and genetics play major roles in its development. About 1.9 percent of African-Americans have psoriasis, compared to 3.6 percent of Caucasians. Pustular psoriasis can occur on any part of the body, but occurs most often on the hands or feet. Non pustular psoriasis has two sub classifications that include psoriasis vulgaris (plaque psoriasis) and psoriatic erythroderma (erythrodermic psoriasis).
Psoriasis is a complex, chronic, multifactorial, inflammatory disease that involves hyperproliferation of the keratinocytes in the epidermis, with an increase in the epidermal cell turnover rate (see the image below). Plaque psoriasis: Most commonly affects the extensor surfaces of the knees, elbows, scalp, and trunk. Psoriatic arthritis: Affects approximately 10-30 of those with skin symptoms; For purposes of treatment planning, patients may be grouped into mild-to-moderate and moderate-to-severe disease categories. Psoriasis is a term that describes a condition of the skin of two main varieties, pustular and nonpustular, along with several less common varieties. This type of psoriasis is charaterized by raised bumps or pustules that contain non-infectious pus. Pustilar psoriasis is broken down into several sub-categories:.
Skin rapidly grows and accumulates at psoriatic plaques, i.e., red scaly patches. 62 Erythrodermic Psoriasis. 2. Is the patient disabled by the psoriasis? 3. Does the psoriasis have a significant impact on the patient s quality of life? 4. The patient is not a candidate for phototherapy or systemic treatment. It may be extensive with plaques, pustules or erythroderma. Quality of Life and Severity Disease severity classifications serve as a reference point for the physical aspects of the disease, but not the emotional and social aspects. Psoriasis (Ps) is a T-cell-mediated chronic inflammatory disorder of the skin seen in about 3. Nearly, two-thirds of children manifest with plaque-type Ps vulgaris 33.
Psoriasis: Practice Essentials, Background, Pathophysiology
Some, but not all patients, have a first degree relative with psoriasis. The vulgaris type with scale is a chronic form, while the pustular type is eruptive. JEADV 2011, 25, 417421 Figure 2 Psoriatic nails in a child. Palmoplantar Pustular Psoriasis Efficacy and Safety wIth Secukinumab. Non-controlled Study of KHK4827 in Subjects With Psoriasis. Study Phase: Phase 2. Special feature which is seen only in inverse psoriasis is: (AIIMS May 2012) A Pitting of nails B Beau’s lines C Auspitz sign D Flexural involvement. Most cases of Pityriasis rosea clear up within- (LQ) A 1 to 2 daysB 1 to 2 weeks C 6-8 daysD 6 to 8 weeks. Koebner phenomenon is not seen in: (AIPG 2011) A PsoriasisB Lupus vulgaris C vitiligo. The method according to claim 10, wherein the psoriasis is psoriatic skin lesions or psoriatic nail lesions. The topical composition according to claim 1, wherein the psoriasis is selected from chronic plaque psoriasis, guttate psoriasis, erythrodermic psoriasis, pustular psoriasis, and the combinations thereof. Chronic plaque psoriasis, also known as vulgaris psoriasis, is most commonly seen amongst all the types of psoriasis, and around 80 -90 of psoriasis patients belong to this type. Guttate psoriasis is characterized by numerous small pink or red teardrop-shaped lesions on patients’ skins and usually occurs in children from age 7 to age 10, in which most of the patients are found to have suffered a streptococcal infection one or two weeks before the onset of the disease. Those suffering from Psoriasis generally have red, scaly patches on their skin. Psoriasis can by graded into mild, moderate and severe categories. In Psoriatic Erythroderma, there is widespread inflammation, swelling, itching, exfoliation of skin and pain over most parts of the body.
3-1 and 3-2); scales may not be visible but become apparent upon scraping. Ten to fifteen percent of people with psoriasis have psoriatic arthritis. Plaque psoriasis (psoriasis vulgaris) (L40.0) is the most common form of psoriasis. Plaque-like psoriasis); Psoriatic erythroderma (Erythrodermic psoriasis).