J Am Acad Dermatol. 1997 Aug;37(2 Pt 3):S18-24. Molecular mechanisms of tazarotene action in psoriasis. Duvic M(1), Nagpal S, Asano AT, Chandraratna RA. Psoriasis is a chronic immune-mediated disease that is characterized by the hyperproliferation and abnormal differentiation of keratinocytes and by inflammation. Molecular mechanisms of Tazarotene action in psoriasis on ResearchGate, the professional network for scientists.
Molecular mechanisms of tazarotene action in psoriasis. HH, Leffers, H et al, Molecular cloning occurrence, and expression of a novel partially secreted protein psoriasin that is highly up-regulated in psoriatic skin. This paper focuses on the cutaneous mechanisms of action of corticosteroids and on the currently available topical treatments, taking into account adverse effects, bioavailability, new combination treatments, and strategies to improve the safety of corticosteroids. According to Cornell and Stoughton, we know that the vehicle can directly modify a preparation s therapeutic and adverse effects by changing the pharmacokinetics of the topical corticoid molecule. It is not indicated to prescribe tazarotene mixed with corticosteroids. The tazarotene-induced gene 1 (TIG1) was chosen for further study. TIG1 expression in normal tissues and cell lines was analyzed by northern blot and in normal and tumor prostate tissue sections by in situ hybridization. Molecular mechanisms of tazarotene action in psoriasis. J Am Acad Dermatol 1997;37(2 Pt 3):S18 24.
Psoriasis: The mechanism of tazarotene action in psoriasis is not defined. Topical tazarotene blocks induction of mouse epidermal ornithine decarboxylase (ODC) activity, which is associated with cell proliferation and hyperplasia. In addition to reviewing the clinical presentation of psoriasis in the lower extremity, this author provides key insights on various topical medications ranging from corticosteroids and vitamin D analogs to retinoids and keratolytics. Molecular mechanisms of tazarotene action in psoriasis. Molecular mechanisms of tazarotene action in psoriasis. Duvic M, Nagpal S, Asano AT, Chandraratna RA. Journal of the American Academy of Dermatology.
References In Molecular Mechanisms Of Tazarotene Action In Psoriasis
The mechanism of action of tazarotene in the treatment of basal-cell carcinoma is not known. Molecular effects similar to those observed in the case of psoriasis may mediate the therapeutic effect reported here for basal-cell carcinoma.