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Mice show link between psoriasis and heart disease

Scientists are aware of the connection between psoriasis and CVD, but it was unknown how the two diseases were linked. In addition, Ward and her team investigated whether or not psoriasis mice would also show cardiac complications, identical to those seen in human disease. Why Does Psoriasis Increase Risk for Obesity, Heart Disease? From what I’ve read, doctors believe there is a correlation between obesity and fibromyalgia, and a correlation between obesity and psoriasis, and that both are related to inflammation. Research shows there could be some inflammatory process that’s common to psoriasis, as well as other comorbidities, she said. For many years doctors have observed a link between the skin condition psoriasis and cardiovascular disease, but how the two could be linked has remained a mystery.

Mice show link between psoriasis and heart disease 2The link between psoriasis and cardiovascular events has been observed for years, however the mechanics were unknown. Published in the Journal of Investigative Dermatology, the study used a new, innovative mouse model to demonstrate a causal connection between the skin disease and cardiovascular disease. There has been a link between the two diseases but to date we had not been able to show cause. For the first time, researchers have linked psoriasis to the risk of widespread bone loss and describe how the protein IL-17 acts as a ‘messenger’ between the skin and the bones. Left, shows a histological image of healthy mouse bone. It is characterised by inflammation and scaling of the skin, accompanied by a greater risk of contracting some type of metabolic syndrome, predisposing patients to pathologies, such as obesity, diabetes or cardiovascular diseases. The relationship between psoriasis and other diseases has drawn increasing interest in recent years.

Keywords: atherosclerosis, cardiovascular disease, inflammation, psoriatic arthritis. These results were in contrast to a different study that used information from the same database that did not show a difference in cardiovascular risk between methotrexate monotherapy compared with other nonbiologic medications in patients with psoriatic disease Chen et al. Drug Shows Promise Against Arthritis Common in People with Psoriasis. Psoriasis and psoriatic arthritis diseases illustrate that immune-mediated activated crossroads of inflammation beyond enhanced cardiovascular risk factors are the result of an interplay between different proatherogenic mediators derived from metabolic, vascular and autoimmune joint and skin inflamed target tissue. Epidemiological studies show a peak in incidence between the second and third decades in life 5.

Preclinical Evidence Demonstrates Link Between Psoriasis And Cardiovascular Disease

Given the bidirectional link between inflammation and thrombosis, arterial thrombosis was assessed in KC-Tie2 and control mice; mean time to occlusive thrombus formation was shortened by 64 (P 0. Biomarkers associated with CVD risk were examined in KC-Tie2 mice. Danish researchers found that people with type 2 diabetes had more than 50 percent greater odds of having psoriasis compared to people without diabetes. The Strange Link Between Psoriasis and Depression. The researchers gave mice excess Tie-2 protein in their skin, to give a similar skin condition to human psoriasis, which affects 2 to 6 million Americans. There has been a link between the two diseases but to date we had not been able to show cause. Vascular endothelial growth factor (VEGF) is a potent mediator of angiogenesis, prompting recent efforts to therapeutically exploit this factor in conditions involving pathologically decreased blood flow, such as ischemic heart disease and nonhealing skin ulcers. In addition, a chronic inflammatory skin condition developed in mice in which CD18 was knocked out, but only when the CD18-deficient 129/Sv mice were backcrossed onto the PL/J strain. Young K14-VEGF transgenic mice display a mild pre-psoriatic phenotype. VEGF is likely a key factor in the link between inflammation and angiogenesis. An important comorbidity of patients with psoriasis is cardiovascular disease (CVD), including coronary heart disease, stroke, peripheral artery disease, and heart failure. 8 As severe psoriasis (but not mild psoriasis) is considered to be an independent risk factor for cardiovascular mortality,6 the K14-IL-17Aind/+ mice which develop a severe form of psoriasis-like skin disease seemed to be an ideal model to study the correlation between psoriasis and vascular disease in the mouse model. We here show that overexpression of IL-17A in keratinocytes induces systemic vascular inflammation, endothelial dysfunction, and arterial hypertension driven by MPO+ cells, leading to increased mortality. Psoriasis is a chronic autoimmune disorder that affects 2 of the world population. It is characterised by inflammation and scaling of the skin, accompanied by a greater risk of contracting some type of metabolic syndrome, predisposing patients to pathologies, such as obesity, diabetes or cardiovascular diseases. The current study shows how this mouse model suffers from bone loss.

Atherosclerosis In Psoriatic Disease: Latest Evidence And Clinical Implications

Dr. Ward and her team measured blood clot formation in the psoriasis mouse model and normal mice revealing that time was greatly shortened in the diseased mice. Ward and her team set-out to investigate whether their mouse model of psoriasis would also show cardiac complications mimicking these seen in human disease. Mechanistic discovery links psoriasis to increased risk of cardiovascular disease The link between psoriasis and cardiovascular events has been observed for years however the mechanics were unknown. ‘Designer Cells’ Show Promise Against Psoriasis in Lab Mice. Prior research has also linked to increased risks of depression and physical ills like diabetes and heart disease — possibly because of chronic inflammation in the body. Psoriasis is a chronic skin disease that affects about 2 of the population. Furthermore, since it was shown that patients suffering from psoriasis exhibit an increased intestinal permeability, it is assumed that there is a correlation between psoriasis and the health of the intestine (Humbert P et al. In fact, biopsies of psoriatic lesions show significantly increased expression of CRH compared to normal skin, suggesting a possible role of CRH in the underlying pathophysiologic mechanism of the disease 22. The link between melatonin and diabetes has not yet been fully elucidated, but DMII is associated with decreased levels of melatonin, and recent genome-wide association studies have demonstrated that single nucleotide polymorphisms of the MT2 melatonin receptor locus significantly increase the risk for developing DMII 78 80.

Although the skin disease psoriasis was first recognized as a distinct disease as early as 1808 (1), its pathogenic mechanisms have eluded investigators for decades. The fsn gene has been mapped to the distal end of mouse chromosome 17 between D17Mit75 and D17Mit129 (120) which is homologous to human chromosome 2p21 22 (121). Psoriasis patients show signs of insulin resistance.