Methotrexate-Induced Papular Eruption Following Treatment of Psoriasis on ResearchGate, the professional network for scientists. To report a case of a diffuse papular eruption following treatment of psoriasis with methotrexate injections. A 52-year-old woman presented with an extensive flare of psoriasis associated with joint pain, especially in her knees and elbows. Methotrexate-induced papular eruption appears in patients being treated with methotrexate, such as those with rheumatic disease, presenting with erythematous indurated papules, usually located on the proximal extremities. Jump up Mebazaa A, Kenani N, Denguezli M, et al. (January 2008). Methotrexate-induced papular eruption following treatment of psoriasis.
Methotrexate is an antimetabolite used as a treatment for a variety of neoplastic and inflammatory diseases. The Food and Drug Administration has given methotrexate indications for the treatment of psoriasis, rheumatoid arthritis, and juvenile rheumatoid arthritis. Others skin eruptions, in particular those following high dose methotrexate treatment, appear to result from cytotoxic-T lymphocytes and mononuclear cells that induce apoptosis in keratinocytes expressing drug-derived antigens at their surfaces, which is unsurprising because methotrexate can induce apoptosis 7, 8. Three cases of toxic skin eruptions due to methotrexate and a compilation of methotrexate induced skin eruptions. Methotrexate-Induced Papular Eruption Following Treatment of Read more about papular, methotrexate, psoriasis, eruption, collagen and vascular. Superficial Tissue Necrosis Related to Methotrexate Injection in a Patient With Rheumatoid Arthritis. Methotrexate-induced papular eruption following treatment of psoriasis.
Pustular eruption following administration of cefazolin: a second case report. Methotrexate-induced papular eruption following treatment of psoriasis. More. Methotrexate (MTX) can be given as a pill or as an injection to alleviate symptoms of severe psoriasis or psoriatic arthritis. so-ri ah-sis a chronic, recurrent skin disease marked by discrete bright red macules, papules, or patches covered with lamellated silvery scales. Guttate psoriasis is characterized by the acute onset of small, 1-10 mm diameter, droplike, erythematous-to-salmon-pink papules, usually with a fine scale, as demonstrated in the images below. Streptococcus pyogenes) often precedes the eruption by 2-3 weeks. The sudden appearance of the papular lesions in response to streptococcal infection could either be the first manifestation of psoriasis in a previously unaffected individual or an acute exacerbation of long-standing plaque psoriasis.
Three Cases Of Toxic Skin Eruptions Due To Methotrexate And A Compilation Of Methotrexate Induced Skin Eruptions
Methotrexate and liver function: a study of 13 psoriasis cases treated with different cumulative dosages. Methotrexate-induced papular eruption following treatment of psoriasis. This has important clinical consequences, because such patients tend to be treated with broad-spectrum antibiotics which may lead to antibiotic resistance and suboptimal therapy. Stevens-Johnson syndrome (7-14 days after first drug exposure or within three days of second exposure ) – see below. The number of events recorded during or after treatment was 56 for adalimumab (0. A papular rash was described in three cases, with localization around the eyes, on the back, and once on the back and lower legs. Infliximab and methotrexate in the treatment of rheumatoid arthritis. Therefore, management of psoriasis involves addressing both psychosocial and physical aspects of the disease. Established therapies such as methotrexate and phototherapy continue to play a role in the management of moderate to severe plaque psoriasis. Pregnancy is contraindicated for three years following acitretin therapy. When compared with calcipotriene, calcitriol appears to induce less irritation in sensitive areas of the skin (eg, skin folds) 25. To investigate anti-TNF-a induced psoriasis, we conducted a systematic analysis of the 6 cases we observed among our inflammatory patient cohort treated with anti-TNF-a (infliximab or etanercept). In light of previously published cases describing psoriasis or psoriasiform lesions after TNF-a antagonist therapy, our series strongly confirms that TNF-a antagonists may induce psoriasis in some patients. The adverse effects of TNF-a antagonists include skin abnormalities8, which have been well documented in RA and consist chiefly of skin infections, eczema, and drug-related eruptions. In May 2004, after the 25th infliximab infusion, erythematous, papular, scaly lesions developed in the inguinal folds and over the pubis, umbilical area, and legs. All drugs may induce skin reactions, although if they do occur they are usually mild, however, some skin reactions are serious and potentially life-threatening. Shaving for women – if after shaving your legs a rash appears do not shave again until the skin has completely healed. Most sking reactions occur within two to three weeks of initiation of chemotherapy and resolve 10 to 12 weeks after stopping treatment. The lesions in acne like rashes are papular and pus filled but blackheads are usually absent.