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Metabolic Syndrome, a Risk Factor for Heart Disease and Diabetes, More Likely in People With Psoriasis

Cardiovascular disease, obesity, diabetes, hypertension, dyslipidemia, metabolic syndrome, nonalcoholic fatty liver disease, cancer, anxiety and depression, and inflammatory bowel disease have been found at a higher prevalence in psoriasis patients compared to the general population. Metabolic syndrome has been estimated to affect up to 24 percent of American adults, with the highest prevalence in people ages 60 through 69. In addition, the study found that people with metabolic syndrome have a higher risk of dying of heart attack or cardiovascular disease. Menter and his co-authors advise that patients with psoriasis should be evaluated for risk factors of metabolic syndrome and provided appropriate treatment, if necessary. Insulin Resistance: Risk Factor for Heart Disease and Diabetes. Insulin resistance is a metabolic disorder that occurs when the body’s cells cannot properly intake insulin. Insulin resistance has also been associated with acne and psoriasis, though most people with those conditions are not insulin resistant, according to the article. People who have symptoms of metabolic syndrome, a constellation of symptoms including higher blood sugar, excess body fat around the abdomen, elevated cholesterol and high blood pressure, are also very likely to have insulin resistance, according to a 2003 article in the journal Diabetes Care.

Metabolic Syndrome, a Risk Factor for Heart Disease and Diabetes, More Likely in People With Psoriasis 2The more severe the psoriasis, the greater the likelihood of type 2 diabetes. This could be due to excess inflammation or to an increased risk of obesity and other risk factors for cardiovascular disease. Some psoriasis treatments may cause abnormal cholesterol levels and increase the risk of hardened arteries. People with psoriasis have a higher risk of metabolic syndrome. Celiac disease, sclerosis and the inflammatory bowel disease called Crohn’s disease are more likely to strike people with psoriasis. If you have severe psoriasis, you have a greater risk for stroke, heart attack, and diabetes. Yet psoriasis can be a serious health threat for some people. Metabolic syndrome is the name given to a group of risk factors for heart disease and other serious health problems. Researchers showed that people who also have psoriasis are more likely to die from cardiovascular disease or have repeated heart attacks and strokes than those without psoriasis. Metabolic syndrome refers to the combination of obesity, hypertension, dyslipidaemia and insulin resistance. The greater the number of risk factors, the greater the chance of developing heart disease, diabetes, or stroke. Fat stored in the abdominal region is more likely than in other sites to break down into free fatty acids (lipolysis), which get deposited in the liver. They also decrease insulin resistance and may prevent the onset of diabetes in people with metabolic syndrome although their use for this is controversial.

Reduce the effects of psoriasis, inflammation, and your risk of cardiovascular disease with healthy lifestyle choices from DermaHarmony. High blood pressure, high cholesterol, smoking, diabetes, and obesity are more prevalent in psoriasis sufferers than in those without psoriasis, as well as being the primary risk factors for heart disease. As problematic inflammatory components, each of these is also a risk factor for both type 2 diabetes and cardiovascular disease. While an association between psoriasis and metabolic syndrome is reported in the literature, the actual mechanisms for this association have yet to be elucidated, although a great deal of work is being done in this area. Psoriasis is an independent risk for Type 2 Diabetes, according to a new study, with the greatest risk seen in patients with severe psoriasis. Researchers estimate that an additional 115,500 people will develop diabetes each year due to the risk posed by psoriasis above and beyond conventional risk factors. In addition to having an increased risk of diabetes, people with psoriasis are more likely to have metabolic syndrome, high triglycerides, and raised glucose levels, even if they are not overweight or have other common risk factors for these conditions. Association between psoriasis and the metabolic syndrome. The proportions of components of the metabolic syndrome (ischemic heart disease, hypertension, diabetes, obesity and dyslipidemia) were compared between case and control patients by univariate analyses. Lack of echocardiographic and Doppler abnormalities in psoriatic arthritis patients without clinically evident cardiovascular disease or classic atherosclerosis risk factors. RESULTS: Metabolic syndrome was significantly more common in psoriatic patients than in controls (30.

Psoriasis Complications

Metabolic syndrome is a clustering of at least three of five of the following medical conditions: abdominal (central) obesity, elevated blood pressure, elevated fasting plasma glucose, high serum triglycerides, and low high-density lipoprotein (HDL) levels. Metabolic syndrome is associated with the risk of developing cardiovascular disease and diabetes. The most important risk factors are diet (particularly sugar-sweetened beverage consumption), 5 genetics, 6 7 8 9 aging, sedentary behavior 10 or low physical activity, 11 12 disrupted chronobiology/sleep, 13 mood disorders/psychotropic medication use, 14 15 and excessive alcohol use. Psoriasis raises the risk of type 2 diabetes, depending on the intensity of the skin disorder. Psoriasis has been found to be an independent risk factor for type 2 diabetes, with a much greater risk found in those with severe psoriasis. Azfar said, In addition to having an increased risk of diabetes, people with psoriasis are more likely to have metabolic syndrome, high triglycerides, and raised glucose levels, even if they are not overweight or have other common risk factors for these conditions. New research suggests psoriasis, a skin disorder, leads to artery inflammation and increases heart disease risk. Senior investigator, Dr. A portion of people with this skin condition also have psoriatic arthritis. Those who are overweight are more likely to have a worse condition, and there is a possibility that eating less can reduce symptoms and signs. Having psoriasis increases the risk that a person will also have a dangerous clustering of risk factors for heart disease and diabetes known as metabolic syndrome. Psoriasis often occurs alongside metabolic syndrome, obesity, and type 2 diabetes, and research now suggests that there may be a linked genetic cause. Psoriasis was present in 7.6 percent of those with diabetes, but it was only present in 4. Gelfand, of the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, says that the findings have clear implications for clinical practice, especially for dermatology, where he says a major practice gap remains in the screening and counseling of patients for cardiovascular risk factors. People with psoriasis more likely to get other diseases. The more risk factors you have, the higher your risk of getting heart disease. If you have all of the risk factors, you are 6 times as likely to get heart disease. Only about 10 of people with psoriasis had no features of metabolic syndrome. Chronic inflammation can also contribute to heart disease, development of hypertension and diabetes. The risk of ischemic heart disease (IHD) hospitalizations was compared between psoriasis patients and a matched reference cohort.

Psoriasis And Cardiovascular Disease

Kidney disease and psoriasis: novel evidences beyond old concepts. Exploring the association between cardiovascular and other disease-related risk factors in the psoriasis population: the need for increased understanding across the medical community. Psoriasis is associated with type 2 diabetes, obesity, and BMI in adults, and may have a genetic association with obesity. Psoriasis has been associated with components of the metabolic syndrome, particularly obesity and type 2 diabetes mellitus, researchers wrote in JAMA Dermatology. Twins with psoriasis had a higher BMI compared with co-twins without the condition and were also more likely to be obese. Psoriasis Linked to Diabetes People With Severe Psoriasis at Twice the Risk of New-Onset Diabetes WebMD Health News By Charlene Laino Reviewed by Louise Chang, MD More from WebMD Psoriasis. Cut Heart Attack Risk People on TNF Inhibitors, Oral or Light Therapy Less Likely to Have Heart Attacks, Researchers Find WebMD Health News By Kathleen Doheny. Metabolic Syndrome, a Risk Factor for Heart Disease and Diabetes, More Likely in People With Psoriasis WebMD Health News By Brenda Goodman,. Having psoriasis also increases your risk of developing high blood pressure, which can lead to stroke or heart attack.

Also, women with psoriasis are three times more likely to suffer several other health problems called comorbidities, such as lupus or MS. Metabolic syndrome: Listed as obesity, diabetes, hypertension. Diabetes: Chronic inflammation is the most important contributing factor for the increased risk in type 2 diabetes. Cardiovascular disease: People with psoriasis have a 58 percent higher risk of developing heart disease, especially those with severe psoriasis.