Skip to content

Key words: Pustular psoriasis, adalimumab therapy, biologic therapy of psoriasis

Key words: Pustular psoriasis, adalimumab therapy, biologic therapy of psoriasis 1

Keywords: Adverse effects, biologics, psoriasis, therapy. Open label trial of alefacept in palmoplantar pustular psoriasis. Keywords: psoriasis, adalimumab, tumor necrosis factor alpha. Duvic M. Generalized pustular psoriasis following withdrawal of efalizumab. We report here the treatment of an adolescent girl who responded to adalimumab after failing to respond to a combination of methotrexate, cyclosporin and isotretinoin, and having had a pustular reaction that followed the use of etanercept, but might have been triggered by an infection. Key words: Pustular psoriasis, adalimumab therapy, biologic therapy of psoriasis.

Key words: Pustular psoriasis, adalimumab therapy, biologic therapy of psoriasis 2However, long-term treatment in patients with moderate to severe psoriasis is limited by the potential for toxic effects on organs, such as renal, hepatic or bone marrow, in addition to teratogenicity and malignancies that are associated with the traditional systemic therapies. Four biologic therapies (adalimumab, efalizumab, etanercept and infliximab) which had been thoroughly revised, are now licensed for the treatment of moderate-to-severe psoriasis. Biologics Childhood Pediatric psoriasis Systemic treatments. Acitretin is a second-generation aromatic retinoid suitable for children with generalized flares and pustular psoriasis as intermittent rescue therapy and in case of pustular, erythrodermic or severe plaque psoriasis of older children as long-term therapy 30. Adalimumab is a monoclonal antibody against TNF. Biological therapies of proven benefit in severe psoriasis include etanercept, adalimumab and infliximab, which target tumour necrosis factor. Key words: adalimumab, efalizumab, etanercept, infliximab, ustekinumab.

Key Words: biologic agents, childhood, pediatric psoriasis. There are two case reports in the literature detailing the successful use of adalimumab for recalcitrant pustular psoriasis in adolescent girls after failure of other systemic and biologic agents. Keywords: Biologics; proteins; autoimmune diseases. In a trial, patients with psoriatic arthritis received adalimumab every other week for 24 week14. Successful treatment for severe psoriasis and generalised pustular psoriasis has been reported with basiliximab, an interleukin-2 receptor (IL-2R; CD25) chimeric monoclonal antibody 18, 19. However, the patient refused to receive treatment with a biological agent.

Biologic Systemic Therapy For Moderate-to-severe Psoriasis: A Review

Goeckerman therapy at the UCSF Psoriasis Center were followed from admission to discharge 3Therapeutic approaches to generalized pustular psoriasis and psoriatic arthritis are discussed separately. Data are limited on the efficacy of biologic agents other than infliximab for the treatment of erythrodermic psoriasis. Key words: drug therapy; psoriasis. Second-line systemic therapies for PPPP are the biologic agents, alefacept, adalimumab, etaner- cept, and infliximab (Fig 5). In other forms of psoriasis, the use of etanercept, as that of other biological therapies, has been published in an isolated way with satisfactory results. Keywords. Generalized pustular psoriasis-Von Zumbusch, Palmoplantar psoriasis, Hallopeau acropustulosis perstan, Erythrodermal psoriasis, Etanercept. Induction and exacerbation of psoriasis with TNF-blockade therapy: a review and analysis of 127 cases. Successful treatment of recalcitrant palmoplantar pustular psoriasis with sequencial use of infliximab and adalimumab. Biologic therapies, including tumor necrosis factor inhibitors, can be effective for severe psoriasis and psoriatic arthritis, but have significant adverse effect profiles and require regular monitoring. Atypical forms include guttate, pustular, erythrodermic, and inverse psoriasis. Data Sources: A PubMed search was completed in Clinical Queries using the key terms psoriasis, arthritis, etiology, and treatment. Pustular psoriasis, which occurs in less than 3 percent of patients. It appears as blisters on the skin, which become reddened and may appear in specific spots, mainly on the hands and feet or on the tips of the fingers, or in widespread patches on the body. Psoriasis? Biologic therapies are systemic medications that target specific proteins in the body. Humira is also indicated for the treatment of psoriatic arthritis. Use of this site is subject to our terms of use and privacy policy.

The Evolving Role Of Biologics In The Treatment Of Pediatric Psoriasis