When a specific gene is found to be linked to psoriatic disease, researchers work to determine what the gene does under normal conditions. Scientists now believe that at least 10 percent of the general population inherits one or more of the genes that create a predisposition to psoriasis. Like other common diseases, psoriasis runs in families and has been thought to have a genetic component, but it’s been difficult to pin down the genes involved. But mutations in the gene do not only occur in families with a genetic predisposition. These findings suggest both a genetic susceptibility and an environmental response in developing psoriasis. Some of these genes are also involved in other autoimmune diseases.
Psoriasis is a chronic inflammatory disease of the skin. While the exact cause of psoriasis is unknown, genetic and environmental factors play an important role in its development 5. At present, it is believed that both genetic susceptibility and environmental factors are important in the development of psoriasis. To begin to identify psoriasis disease-related genes and construct in vivo pathways of the inflammatory process, a genome-wide expression screen of multiple psoriasis patients was undertaken. Several psoriasis susceptibility loci have been mapped: PSORS1 on 6p21.3, PSORS2 on 17q, PSORS3 on 4q, PSORS4 on 1cen-q21, PSORS5 on 3q21 and PSORS6 on 19p13.
However, genetic predisposition DNA testing for psoriasis has led researchers to believe that there is a link between psoriasis and genetic activity, which could lead to improved treatment of the condition or perhaps even a cure. Knowing which genetic disorders and diseases you are at risk from will allow you to plan to reduce it by making lifestyle changes such as diet and exercise. Psoriasis is a complex disease due to the interaction between environmental factors and susceptibility alleles. Life style, diet, smoking, stress and infections are the best validated environmental factors predisposing to the pathology. Psoriasis is recognized as a complex disease for which multiple genetic and non-genetic factors influence susceptibility. The major susceptibility locus resides in the MHC class I region and, until relatively recently, evidence for non-MHC loci was inconsistent.
Genetics Of Psoriasis And Pharmacogenetics Of Biological Drugs
Though psoriasis is a common skin disease, its definition by Ferdinand von Hebra as a distinct entity dates back only to the year 1841, and estimates of its prevalence around 2 percent, according to standard textbooks stem from only a few population-based studies. Numerous family studies have provided compelling evidence of a genetic predisposition to psoriasis, although the inheritance pattern is still unclear. The distribution of a rash depends on factors both intrinsic and extrinsic to the body. Psoriasis and the rare hereditary blistering disorders collectively called epidermolysis bullosa owe their distributions to local trauma; lesions that show a predilection for the elbows, knees, and lower back are common in psoriasis, and those found in the hands, feet, knees, and mouth of children are indicative of epidermolysis bullosa. Psoriasis is a long-term (chronic) scaling disease of the skin, which affects 2 3 of the UK population. Genetic predisposition means an inherited tendency to develop the disease.