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Interleukin-23 in the Pathogenesis and Treatment of Psoriasis

Interleukin-23 in the Pathogenesis and Treatment of Psoriasis 1

Abstract: In the past three decades, major advances have been made in understanding the pathogenesis of psoriasis. The currently accepted theory is that. Interleukin-23 and interleukin-17: Importance in pathogenesis and therapy of psoriasis on ResearchGate, the professional network for scientists. 8 issue)1 show that an interleukin-12/23 monoclonal antibody is an effective treatment for psoriasis. The production of aberrant helper T-cell type 1 cytokines, including interleukin-12 and interleukin-23, has long been considered to play an important role in the pathogenesis of psoriasis.

Interleukin-23 in the Pathogenesis and Treatment of Psoriasis 2Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris. IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis. Langley, R. G. Effective and sustainable biologic treatment of psoriasis: what can we learn from new clinical data? J. Interleukin-23 and interleukin-17: importance in pathogenesis and therapy of psoriasis. Essential cells and molecules in the pathogenesis of psoriasis lesions. The interleukin (IL)-23IL-17 axis is well understood in psoriasis.

Specific targeting of interleukin-23p19 as effective treatment for psoriasis. Interleukin 17A (IL-17 or IL-17A), originally identified as a transcript from a rodent T-cell hybridoma by Rouvier et al. The anti-IL-23 antibody ustekinumab can also be used to effectively treat psoriasis by reducing IL-17. Interleukin-23 and interleukin-17: importance in pathogenesis and therapy of psoriasis. Review of ustekinumab, an interleukin-12 and interleukin-23 inhibitor used for the treatment of plaque psoriasis Nora Koutruba, Jason Emer, Mark LebwohlMount Sinai School of Medicine, New York, USAAbstract: The pathogenesis of psoriasis is unknown, although it is generally accepted that this chronic inflammatory skin disorder is a complex autoimmune condition similar to other T-cell mediated disorders. Recently, CD4+ T helper (Th) 17 cells and interleukins (IL)-12 and -23 have been important in the pathogenesis of T-cell mediated disorders such as psoriasis and has influenced the development of medications that specifically target these key immunological players.

Clinical Improvement In Psoriasis With Specific Targeting Of Interleukin-23

Pathophysiology of psoriasis: recent advances on IL-23 and Th17 cytokines 3PubMed journal article Interleukin-12, interleukin-23, and psoriasis: current prospect was found in Unbound MEDLINE. Interleukin (IL)-12 and, more recently, IL-23 have been implicated in the pathogenesis of psoriatic lesions. New therapies, including a monoclonal antibody against a subunit shared by IL-12 and IL-23, have been developed to treat psoriasis. Interleukin-23 inhibitor has ‘high efficacy, quiet safety signal. A pathogenic role of T cells has not been considered. IL-23, is an effective treatment modality for patients in whom GPP treatment with conventional psoriasis drugs or antagonists of tumor necrosis factor (TNF) has not been sufficiently effective, is contraindicated, or has lost efficacy. Interleukin 12/Interleukin 23 Blockade in Severe Psoriasis. E2. Genetics, Pathogenesis, Psoriasis, Psoriatic arthritis. New concepts in the pathogenesis and treatment of psoriasis: key roles for IL-23, IL-17A and TGF- 1. Although early concepts of the pathogenesis of psoriasis focused prima.

References In Specific Targeting Of Interleukin-23p19 As Effective Treatment For Psoriasis

As we described in the previous chapter, Th17/IL-23 axis plays an important role in immune pathogenesis of psoriasis and PsA., Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris, The Journal of Experimental Medicine, vol. Interleukin-23 (IL-23) is a heterodimeric cytokine, consisting of a unique IL-23p19 subunit paired with a common IL-12/23p40 subunit, which is shared with IL-12 1. In the past 3 years major advances in our understanding of psoriasis pathogenesis have arisen from exciting genetic, immunological and clinical findings, all unambiguously converging on the pivotal role of the IL-23/Th17 axis in psoriasis 16.