Arch Klin Exp Dermatol. 1970;236(3):297-314. Inflammatory infiltrate in psoriasis vulgaris. A cytochemical study. Article in German. Braun-Falco O, Burg G. Psoriasis vulgaris is a multi-factorial heritable disease characterized by severe inflammation resulting in poorly differentiated, hyperproliferative keratinocytes. Inflammatory infiltrate in psoriasis vulgaris. A cytochemical study. AU. Braun-Falco O, Burg G. SO. Arch Klin Exp Dermatol. 1970;236(3):297. AD. PMID.
Inflammatory infiltrate in psoriasis vulgaris. A cytochemical study. on ResearchGate, the professional network for scientists. Psoriasis vulgaris is a common skin disorder characterised by focal formation of inflamed, raised plaques that constantly shed scales derived from excessive growth of skin epithelial cells. 22 24 In fact, a significant fraction of dermal mononuclear inflammatory cells seen in routine sections is due to T cell infiltration. Lesions with a silvery white scale characterize psoriasis, a common, noncontagious skin disorder. The disease is caused mainly by anomalies in protein expression in skin cells, and these anomalies can be divided into three areas: abnormal keratinocyte differentiation, hyperproliferation of the keratinocyte, and infiltration of inflammatory elements. This paper will discuss the most common form, plaque psoriasis, or psoriasis vulgaris, which is characterized by swollen red skin lesions with a silvery white scale (Peters 2000).
Psoriasis vulgaris is the most common type of psoriasis, manifested as dry, red raised plaques with adherent silvery scales. Is psoriasis a Th1 and/or Th17 cell-mediated inflammatory skin disease? 60 More importantly, these released Th17-related cytokines can further act on keratinocytes and other inflammatory cells infiltrated in the skin, thus amplifying the local inflammation as well as causing keratinocyte hyperproliferation. Psoriasis is a long-lasting autoimmune disease characterized by patches of abnormal skin. Plaque psoriasis, also known as psoriasis vulgaris, makes up about 90 of cases. Psoriasis Vulgaris presents with inflammatory infiltrate of leukocytes predominantly into the dermis and involves a cell mediated immune response. However the auto-antigen to which the immune response is directed has not been identified.
Because psoriasis plaques are accessible to repeat biopsy, the effect of TNF/lymphotoxin blockade with etanercept (soluble TNFR) was studied in ten psoriasis patients treated for 6 months. Histological response, inflammatory gene expression, and cellular infiltration in psoriasis plaques were evaluated. Severe psoriasis vulgaris can be extremely difficult to treat in some patients, even with the newer biological therapies available today. Psoriasis and psoriatic arthritis diseases illustrate that immune-mediated activated crossroads of inflammation beyond enhanced cardiovascular risk factors are the result of an interplay between different proatherogenic mediators derived from metabolic, vascular and autoimmune joint and skin inflamed target tissue. In addition, NK cells are found in the inflammatory infiltrate in psoriatic skin lesions. Psoriasis is a chronic, proliferative, and inflammatory skin disease affecting 2-3 of the population and is characterized by red plaques with white scales. The most common type of psoriasis is chronic plaque psoriasis or psoriasis vulgaris 6. Psoriasis is one of the most common immune-mediated chronic inflammatory skin disorders, characterized by hyperproliferation of keratinocytes, dilation and growth of dermal capillary vasculature, and cellular infiltration of T cells, dendritic cells (DCs) and neutrophils. Hence, our data suggests that PF can inhibit leukocytes infiltration and decrease the expression of inflammatory cytokines such as IL-17, INF-, IL-6 and TNF-.