Generalized pustular psoriasis (GPP) is an extremely rare type of psoriasis that can present in a variety of forms. Sometimes all or any of GPP is referred to as von Zumbusch psoriasis, but in the literature it is often distinguished as one specific form of GPP. For generalized pustular psoriasis, systemic agents such as retinoids may be required from the beginning of treatment. Widespread pustular psoriasis (von Zumbusch type) affects large areas of skin and can produce a systemic febrile illness. Less common is the juvenile, or infantile type, which occurs in children. Children 2-10 years of age can be affected, but this is rare. Generalized pustular psoriasis (GPP) is a rare type of psoriasis and is considered the most severe variant.
Pustular psoriasis is a rare form of psoriasis that may require different approaches to treatment. H. et al, Therapeutic guidelines for the treatment of generalized pustular psoriasis (GPP) based on a proposed classification of disease severity. S. Treatment of recalcitrant von Zumbusch pustular psoriasis with etanercept: P2753. Psoriasis is a chronic inflammatory disease mediated by a complex interplay between immune system and keratinocytes. Generalized pustular psoriasis (Zumbusch pustular psoriasis) can be found on any location of the body and named after Von Zumbusch, the founder in the early 20th century. Generalized pustular psoriasis (Zumbusch pustular psoriasis) can be found on any location of the body and named after Von Zumbusch, the founder in the early 20th century. Annular pustular psoriasis is a rare variation of pustular psoriasis which has a tendency to spread and form enlarged rings. Infantile pustular psoriasis is a form of pustular psoriasis that tends to occur during infancy.
Initial differential diagnosis included infantile generalized pustular psoriasis and AGEP. Generalized pustular psoriasis is a rare type of psoriasis first described in 1910 by von Zumbusch. Whether onset in childhood predicts a more severe form of psoriasis is a matter of controversy, it may cause significant morbidity particularly if it keeps relapsing. Systemic therapies are reserved for more severe and extensive cases that cannot be controlled with topical treatment and/or phototherapy such as severe plaque type, unstable forms like erythrodermic and generalized pustular psoriasis and psoriatic arthritis. Flexural psoriasis of the genital and periumbilical regions is common and may be the only manifestation of disease; 17 however, such involvement is rare in infantile psoriasis in India. The von Zumbusch pustular psoriasis is more common in infancy whereas annular forms appear later and mixed patterns also occur. Generalised pustular psoriasis also features pus-filled spots, but on any area of the body. People with von Zumbusch pustular psoriasis often need to be hospitalized for rehydration and start topical and systemic treatment, which typically includes antibiotics. Acropustulosis (acrodermatitis continua of Hallopeau) is a rare type of psoriasis characterized by skin lesions on the ends of the fingers and sometimes on the toes. The juvenile, or infantile, type of pustular psoriasis is usually mild.
References In Treatment Of Pustular Psoriasis: From The Medical Board Of The National Psoriasis Foundation
Looking for online definition of pustular psoriasis in the Medical Dictionary? A severe form of psoriasis consisting of bright red patches and sterile pustules all over the body. FA: Successful treatment of Von Zumbusch pustular psoriasis with insiximab. Background: Lymphomatoid papulosis (LyP) is a rare condition within the spectrum of CD30 cutaneous lymphoproliferative disorders that is not well documented in Taiwan. Infantile generalized pustular psoriasis (von Zumbusch) is a rare form of psoriasis.