Indigo naturalis has been demonstrated to be safe and effective in treating skin psoriasis. This trial was conducted to evaluate the efficacy and safety of refined indigo naturalis extract in oil (Lindioil) in treating nail psoriasis. Nail psoriasis treatment is notoriously difficult. While indigo naturalis has been demonstrated safe and effective in treating skin psoriasis, its effect on nail psoriasis remains unverified. Indigo naturalis has been demonstrated to be safe and effective in treating skin psoriasis. This trial was conducted to evaluate the efficacy and safety of refined indigo naturalis extract in oil (Lindioil) in treating nail psoriasis.
Change From Baseline in Single-Hand Nail Psoriasis Severity Index (NAPSI)and in the Modified Target NAPSI for the Single Most Severely Affected Nail of Each Hand at Week 12. While indigo naturalis has been demonstrated safe and effective in treating skin psoriasis, its effect on nail psoriasis remains unverified. An ointment made from indigo naturalis, a dark blue plant-based powder used in traditional Chinese medicine, appears effective in treating plaque-type psoriasis, according to a report in the November issue of Archives of Dermatology. Traditional Chinese medicine is one of the most frequently chosen alternative therapies in China and Taiwan, and psoriasis has been treated for centuries with topical and oral herbal preparations, the authors write. The researchers assessed and photographed patients’ skin plaques at the beginning of the study and again after two, four, six, eight, 10 and 12 weeks. Conclusions: The results suggest that topical application of indigo naturalis ointment may be a novel, safe and effective therapy for psoriasis that is mediated, at least in part, by modulating the proliferation and differentiation of keratinocytes in epidermis, as well as by inhibiting the infiltration of T lymphocytes and therefore the subsequent inflammatory reactions in psoriatic lesions. At the end of treatment, skin punch biopsies were taken and prepared for the immunohistochemical analysis.
Decrease inflammation of the skin by using safe and effective topical anti-inflammatories. There have been several studies which have demonstrated the efficacy of this herb in the treatment of psoriasis. Indigo naturalis has long been used in China to treat different inflammatory skin conditions24. Psoriasis is a chronic inflammatory skin disease that may appear on the skin at any area of the body, in particular head, limbs, elbows, knees, etc. The applicants found that topical application of said ointment was effective in treating pediatric psoriasis, recalcitrant psoriasis and plaque-type psoriasis (Y. The oil-extracted product of indigo naturalis has been demonstrated to be effective in relieving or ameliorating human psoriatic diseases, in particular skin psoriasis and nail psoriasis. Table 9 shows the safety evaluation results of the crude and refined ointments of indigo naturalis as prepared in the above Example 2. Some scholars believe psoriasis to have been included among the skin conditions called tzaraat in the Bible. The history of psoriasis is littered with treatments of dubious effectiveness and high toxicity. In 2004, Tas and Avci demonstrated cyclopamine’s clinical potential for the treatment of psoriasis and basal cell carcinoma in two preliminary proof of concept studies. Indigo naturalis ointment-treated lesions showed an 81 percent improvement, the (nonmedicated) ointment-treated lesions showed a 26 percent improvement.
Evaluation Of The Efficacy And Safety Of Indigo Naturalis Oil Extract On Psoriatic Nails
Rebound of psoriasis following discontinuation of the drug has been reported. Psoriasis may also solely involve the nails, without any other skin findings, in which the treatment can be more challenging. The Nail Psoriasis Severity Index (NAPSI) has been developed as an objective and reproducible tool, which helps to estimate the nail involvement and therefore to standardize the treatment outcome assessments. In the last decade, the introduction of biological agents used for the treatment of plaque psoriasis and psoriatic arthritis has brought a safe and highly effective treatment option for severe nail bed and matrix disease as well. Cholesterol-lowering drugs may contribute to skin disorders. Curcumin was demonstrated to be effective as an adjuvant therapy for the treatment of psoriasis vulgaris and to significantly reduce serum levels of IL-22. EPA and DHA may have a therapeutic effect in patients with psoriasis and psoriatic arthritis. Indigo naturalis (Strobilanthes) is a safe and effective treatment for psoriasis – Article 1. The role of genetic factors has been a matter of research, particularly in the past decades. In a 12-week randomized, controlled, open-label study, the efficacy and safety of topical treatment with tacrolimus 0. It is an effective treatment of skin lesions in psoriasis by inhibiting keratinocyte hyperproliferation and interfering with several relevant steps of the immune system 65. In addition, topical use of indigo naturalis has shown to be effective in PP 73, but its use in nail psoriasis is limited by the recalcitrant and intense blue color.