In 2006, Bernstein et al did a clinical trial involving 200 patients with mild to moderate psoriasis22. The patients who used a topical extract of Barberry showed a significant decrease in their symptoms. Results from clinical trials on the efficacy of biologic therapies for the treatment of psoriasis 22 30. Proportions of patients with moderate-to-severe plaque psoriasis showing improvements in the Psoriasis Area Severity Index of 50 (PASI 50), 75 (PASI 75), and 90. Poor adherence to NB-UVB therapy was also observed by Park et al. 19 21 Recently, a Th22 cell subpopulation (characterized by the secretion of IL-22 and TNF- ) was identified in the epidermis of individuals with psoriasis.22 Th22 clones derived from patients with psoriasis were stable in culture and exhibited a profile clearly separate from those of Th1, Th2, and Th17 cells. In early clinical studies on ustekinumab, confirmable results were seen after both intravenous and subcutaneous administration of the drug (Table 2). In general, side effects did not require treatment adjustment, did not appear to be dose-related, and were not considered serious. 2006;36(5):13091323.
Although children present with the same clinical subtypes of psoriasis seen in adults, lesions may differ in distribution. Gelfand et al. found that the prevalence of psoriasis in childhood in the UK was about 0. Psoriatic diaper rash is seen in young infants and is characterized by sharply demarcated, minimally elevated erythematous plaques in the diaper area, involving the inguinal folds. 2006;54(11):35643572. (b) Clinical skin severity scores of dermatitis in control (n15) and transgenic mice (n15). Although these young transgenic animals did not display a full-blown skin phenotype at this time point, they do exhibit visible phenotypic signs commonly associated with AD, including dry, inflamed skin as a consequence of Np63 transgene induction that was initiated during the early stages of embryogenesis. In a complementary study with human AD patient skin, Kubo et al. 1 metronidazole gel on the skin barrier in 25 women with mild to moderate rosacea.
Psoriasis In Children And Adolescents: Diagnosis, Management And Comorbidities