Importance of Regulatory T Cells in the Pathogenesis of Psoriasis: Review of the Literature on ResearchGate, the professional network for scientists. The evolving knowledge of the role of the immune system in psoriasis has had a significant impact on treatment development. The epidemiology, genetics, clinical features, diagnosis, and management of psoriasis are reviewed separately. Antigenic stimuli contribute to the activation of plasmacytoid dendritic cells and other innate immune cells in the skin. Altered Immunoregulation in Rheumatoid Arthritis: The Role of Regulatory T Cells and Proinflammatory Th17 Cells and Therapeutic Implications. This review article aims to discuss current knowledge on Treg and Th17 cells in RA and possible implications of their therapeutic targeting in this disorder. Besides the crucial and well-characterized role of B lymphocytes in RA pathogenesis, also T cells are active players in this scenario.
Regulatory (‘suppressor’) T cells play a pivotal role in inhibiting the activation and function of effector T cells. Dysfunctional blood and target tissue CD4+CD25 high regulatory T cells in psoriasis: mechanism underlying unrestrained pathogenic effector T cell proliferation. Review Article from The New England Journal of Medicine Psoriasis. HLA-C is an interesting candidate gene, since it might be involved in immune responses at the levels of both antigen presentation and natural killercell regulation. This review discusses the pivotal role of this cytokine in psoriasis pathophysiology, how our understanding of its mechanism evolved and how blocking its effect might substantially improve the condition of people with this disabling skin disease. Hunter et al. wrote More work on cell turnover and its regulation will give the clue to psoriasis. 2, Importance of regulatory T cells in the pathogenesis of psoriasis: Review of the literature.
Regulatory T cells (Tregs) are important in the prevention of psoriasis. Peer-reviewed. (2009) Therapeutic effect of hyperbaric oxygen in psoriasis vulgaris: two case reports and a review of the literature. Importance of regulatory T cells in the pathogenesis of psoriasis: Review of literature. Dermatology 2013;227:134-45. Psoriatic keratinocytes can activate NK-T-cells, but their role in the pathogenesis of human psoriasis is still unclear 35. (2002) Resolution of psoriasis following allogeneic bone marrow transplantation for chronic myelogenous leukemia: case report and review of the literature.
Therapeutic Modulation Of Cutaneous Autoimmunity By Regulatory T Cells
Psoriasis is a long-lasting autoimmune disease characterized by patches of abnormal skin. These skin patches are typically red, itchy, and scaly. One hypothesis is that psoriasis involves a defect in regulatory T cells, and in the regulatory cytokine interleukin-10. The role of insulin resistance in the pathogenesis of psoriasis is currently under investigation. Psoriasis: a T-cell-mediated autoimmune disease induced by streptococcal superantigens? Dysfunctional blood and target tissue CD4+CD25high regulatory T cells in psoriasis: mechanism underlying unrestrained pathogenic effector T cell proliferation. Resolution of psoriasis following allogeneic bone marrow transplantation for chronic myelogenous leukemia: case report and review of the literature. CrossRef. Efficacy and Safety of Tripterygium wilfordii Hook F Versus Acitretin in Moderate to Severe Psoriasis Vulgaris: A Randomized Clinical Trial Chao Wu, Hong-Zhong Jin, Dan Shu, Feng Li, Chun-Xia He, Ju Qiao, Xiao-Ling Yu, Ying Zhang, Yi-Bo He, Tie-Jun Liu Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China Date of Submission02-Oct-2014 Date of Web Publication10-Feb-2015. Importance of regulatory T cells in the pathogenesis of psoriasis: Review of the literature. Cutaneous Complication After BCG Vaccination: Case Report and Review of the Literature. The Journal of Dermatological Treatment. Targeting PKC in Human T Cells Using Sotrastaurin (AEB071) Preserves Regulatory T Cells and Prevents IL-17 Production. The Journal of Investigative Dermatology. Clinical trials successfully using antibodies targeting IL-17 in psoriasis support the importance of IL-17 in the pathophysiology of this disease. However, there is a debate concerning the source and dynamics of IL-17 production in inflamed skin. The pathogenesis of psoriasis involves dynamic interactions between multiple cell types and numerous cytokines in response to triggers, culminating in the disruption of skin immune homeostasis in genetically predisposed individuals. Although the role of regulatory T cells in the pathogenesis of psoriasis remains to be fully elucidated, IL-6 is thought to render effector T cells refractory to regulatory T cell-mediated suppression 113. Phase III studies completed; under FDA review. Pathophysiology of chemokines and chemokine receptors in dermatological science: A focus on psoriasis and cutaneous T-cell lymphoma Volume 30, Issue 4, December 2012, Pages 128-135. We reviewed 173 previously published cases of PEM or so-called animal-type melanoma in the literature.
Plos One: Reactive Oxygen Species Prevent Imiquimod-induced Psoriatic Dermatitis Through Enhancing Regulatory T Cell Function
We further reviewed the literature to characterize the imatinib-induced psoriasis. Immunohistochemical Analysis of Regulatory T Cell Markers FOXP3 and GITR on CD4+CD25+ T Cells in Normal Skin and Inflammatory Dermatoses. Regulatory T cells (Treg) are a subset of T lymphocytes that play a central role in immunologic tolerance and in the termination of immune responses. Consequently, abnormalities in number and function of Treg disturb this control mechanism of immune regulation and may contribute to the pathogenesis of a given disease. This Review summarizes our progress so far towards understanding the role of CD4+CD25+FOXP3+ TReg cells in human autoimmune diseases and the impact that this knowledge might have on the diagnosis and treatment of these diseases.