Psoriasis treatments can be divided into three main types: topical treatments, light therapy and systemic medications. However, anthralin can irritate skin, and it stains virtually anything it touches, including skin, clothing, countertops and bedding. Short-term side effects may include redness, itching and dry skin. Photochemotherapy involves taking a light-sensitizing medication (psoralen) before exposure to UVA light. An assessment of any patient with psoriasis should include disease severity, the impact of disease on physical, psychological and social well-being, whether they have psoriatic arthritis, and the presence of any comorbidities. However, the National Institute for Health and Care Excellence (NICE) guidance, recommending a five-yearly assessment of smoking, alcohol use and blood pressure to all patients with severe psoriasis, is still valid. Topical use of potent corticosteroids on widespread psoriasis can lead to systemic as well as to local side-effects and the development of complications such as erythroderma or generalised pustular psoriasis. Photochemotherapy uses a photosensitising drug (eg, PUVA) to treat patients with more extensive or resistant disease. This medication can cause liver scarring. Long-term potential skin problems can include:.
Treating may include lifestyle changes, nutrition, and medication. Many of these drugs have serious side effects, so doctors limit their use to only difficult or persistent cases. However, intense sun exposure or long-term sun exposure can worsen symptoms. Photochemotherapy, or Psoralen Plus Ultraviolet A (PUVA). Medicine psoralens include methoxsalen (8-methoxypsoralen), 5-methoxypsoralen and trisoralen. Can sunlight be used for PUVA? PUVA has some risks and side effects. However, the psoriasis may later flare up again, and PUVA may be recommenced. Although treatment can provide patients with high degrees of disease improvement, there is no cure for psoriasis. However, even patients on systemic therapy will likely continue to need some topical agents. Side effects of topical corticosteroids, including the potential for suppression of the hypothalamic axis, are discussed separately. Phototherapy and photochemotherapy require the supervision of a dermatologist trained in these treatment modalities.
To educate pharmacists about the different types of psoriasis and the current agents available for the management of this condition. Cancer Some authors postulate that psoriasis may be associated with an increased risk of cancer; however, this could be a side effect of psoriasis treatments, including photochemotherapy. Photochemotherapy has also found a place in the management of subungual hyperkeratosis, onycholysis, discoloration, and nail crumbing in nail psoriasis. Narrowband UVB phototherapy can be administered 3 times per week, starting with a dose equivalent to 50 to 70 of the MED. However, contraindications and side effects are known and should be considered before patients begin a phototherapeutic regimen. Phototherapy and photochemotherapy are well-described treatment modalities for psoriasis in adults. However, clinical findings in the pediatric population may evolve with time. Radiation within the ultraviolet (UV) spectrum can be divided by wavelength into UVA (320 440 nm), UVB (290 320 nm) and UVC (200 290 nm). Long-term side effects include premature photoaging and carcinogenesis.
PUVA therapy was originally developed as a treatment for psoriasis. Read about side effects, types, and effectiveness. PUVA Therapy (Photochemotherapy). Medical Author: Gary W. Psoriasis PUVA Treatment Can Increase Melanoma Risk. PUVA (psoralen and ultraviolet A radiation) treatment has been used for decades to treat severe psoriasis. Psoriasis can affect fingernails and toenails, causing pitting, abnormal nail growth and discoloration. If you have psoriasis, however, the T cells attack healthy skin cells by mistake, as if to heal a wound or to fight an infection. Short-term side effects may include redness, itching and dry skin. Photochemotherapy involves taking a light-sensitizing medication (psoralen) before exposure to UVA light. Certain factors, however, do seem to trigger bouts of the disease. Psoriasis photochemotherapy refers to a specific treatment involving the administration of psoralen with ultraviolet A (UVA) phototherapy, which is usually shortened to PUVA phototherapy. Additionally, rotating PUVA treatment with other therapies indicated for psoriasis can help to reduce the impact of side effects. However, cultured human glia cells do show cell membrane alteration. However, it was not commented on the eczema severity, length of remission, or whether topical treatment was continued during treatment with narrowband UVB 21. Since different forms of phototherapy including 8-methoxypsoralen bath-PUVA psoralen plus UVA (PUVA) are empirically efficient in atopic patients, it is important to compare them systematically. No acute severe adverse effects were reported. Photochemotherapy.