The pathogenesis of psoriasis is not fully understood, but population and twin studies suggest a large heritable component to the etiology. Genetics of Psoriasis: Paternal Inheritance and a Locus on Chromosome 6p. Genetics of Psoriasis: Paternal Inheritance and a Locus on Chromosome 6p. AUTHOR(S). Burden, A. David; Javed, Shaban; Bailey, Mark; Hodgins, Malcolm; The genes from these loci have not yet all been identified, or systematically tested for a role in psoriasis and atopic dermatitis; however, these locations suggest that some susceptibility factors lie within genes or gene families with common effects upon epithelial immunity. In each of the cases described above, psoriasis is inherited as an autosomal dominant trait with reduced penetrance, and the two-point LOD scores exceed the conventionally accepted threshold of 3. Epigenetic markers of imprinting, such as the variable presence of methylation on CpG residues (136) now need to be combined with knowledge of parental disease status as well as parental genotype. (1997) Identification of a major susceptibility locus on chromosome 6p and evidence for further disease loci revealed by a two stage genome-wide search in psoriasis.
In 103 psoriasis affected sib-pair families linkage to 6p (HLA) was detected, but it was most significant in those families without PsA8. D. Genetics of psoriasis: paternal inheritance and a locus on chromosome 6p. Genetics of Psoriasis: Paternal Inheritance and a Locus on Chromosome 6p. Psoriasis is a common inflammatory skin disease with genetic components of both immune system and the epidermis.
F Xiang, S Buervenich, P Nicolao, MES Bailey, Z Zhang, M Anvret. Identification of a Major Susceptibility Locus on Chromosome 6p and Evidence for Further Disease Loci Revealed by a Two Stage Genome-Wide Search in Psoriasis. Whilst data from limited case control associations exist to implicate the MHC, the results of this genome wide analysis demonstrate that, at least in the population studied, a gene or genes located within the MHC and close to the class 1 HLA loci, represent the major determinant of the genetic basis of psoriasis. Allelic association was sought by a genotype-based haplotype relative risk approach that compares genotypes in an affected individual with the two parental alleles that were not transmitted to the affected offspring. Although several genetic loci for psoriasis have been reported, the locus with the strongest effect appears to be the major psoriasis susceptibility 1 (PSORS1) locus within chromosome 6p212. Genetics of psoriasis: paternal inheritance and a locus on chromosome 6p.