Generalized pustular psoriasis successfully treated with topical tacrolimus on ResearchGate, the professional network for scientists. Pustular psoriasis is a rare form of psoriasis that may require different approaches to treatment. F. et al, Generalized pustular psoriasis successfully treated with topical tacrolimus. Pustular psoriasis may be broadly subdivided into localized and generalized forms. Rodriquez GF, Fagundo GE, Cabrera-Oaz R, et al: Generalized pustular psoriasis successfully treated with topical tacrolimus, Br J Dermatol 152:587 588, 2005.
Efficacy and safety of treatments for childhood psoriasis: A systematic literature review. 30Steele, J.A., Choi, C., Kwong, P.C. Topical tacrolimus in the treatment of inverse psoriasis in children. A case of infantile psoriasis with pseudoainhum successfully treated with topical pimecrolimus and low-dose narrowband UVB phototherapy. Evaluation of the effectiveness of childhood generalized pustular psoriasis treatment in 30 cases. Psoriasis is a common papulosquamous skin disease that may be associated with a seronegative spondyloarthropathy. Impetigo herpetiformis and generalized pustular psoriasis must be treated more aggressively because untreated, may lead to serious complications such as sepsis and bacterial superinfection. The most common precipitating factor is the withdrawal of potent topical, oral, and intramuscular corticosteroids. Severe 20-nail psoriasis successfully treated by low dose methotrexate. While mild disease is commonly treated only with topical agents, the use of topical therapy as adjuvant therapy in moderate-to-severe disease may also be helpful and can potentially reduce the amount of phototherapy or systemic agent required to achieve satisfactory disease control. Regardless of the inexistence of studies to prove the assurance of topical corticosteroid use on the scalp beyond 4 weeks, in general, high-potency topical corticosteroids can be successfully and safely used. Nagao, A case of generalized pustular psoriasis treated with topical tacrolimus, Archives of Dermatology, vol.
Penetration of topical tacrolimus can be increased by occlusion. (25) Generalised pustular psoriasis has been successfully treated with topical tacrolimus. Generalized pustular psoriasis of pregnancy (GPP) is a rare entity occurring usually in the third trimester presenting with generalized plaques with peripheral pustules initially from the intertriginous areas disseminating to the rest of the body. Presenting here, an intriguing case of 28-year-old primigravida, in her third trimester with GPP of pregnancy with acrodermatitis continua of Hallopeau (ACH) involving the nails, hands and feet treated successfully with topical steroids. Topical tacrolimus has been tried to alleviate cutaneous manifestations. Pustular psoriasis in children has often a better clinical progression than adults considered as a life-threatening disease. Superficial and sterile pustules may be localized or generalized. Most pediatric patients with childhood psoriasis can be effectively treated by topical therapies at home under supervision of their parents. These agents include tacrolimus and pimcrolimus used in the treatment of atopic dermatitis with no license to treat psoriasis disease.
References In Efficacy And Safety Of Treatments For Childhood Psoriasis: A Systematic Literature Review
There are two common topical drug forms available: tacrolimus 0. Successful treatment of genital and facial psoriasis with tacrolimus ointment 0.1. A case of generalized pustular psoriasis treated with topical tacrolimus. Another condition rarely seen is genital compromise with pustular psoriasis as part of a localized or generalized pustular process, but this complication has only been reported in men 1, 9, 30, 31.