Generalized pustular psoriasis is a rare form of psoriasis consisting of a generalized eruption of sudden onset with erythema and sterile pustules. In this study, we present demographics, clinical aspects, treatment response, and follow-up of seven children with generalized pustular psoriasis. Generalized pustular psoriasis also can cover most of the body. Children rarely develop Von Zumbusch pustular psoriasis, but when it does happen it is often the first psoriasis flare and may have a better outcome than in adults. General pustular psoriasis (GPP), an extremely rare form of psoriasis first described in 1910 by Leo Ritter von Zumbusch, is characterized by an abrupt onset of widespread erythematous lesions followed by superficial yellowish, usually confluent sterile pustules, accompanied by constitutional symptoms such as fatigue and fever 2. Only 1.0 to 5.4 of children have pustular psoriasis 4.
Generalized pustular eruption in a child can be a diagnostic challenge. Acute generalized pustular psoriasis (GPP) is a rare, sometimes fatal, exudative form of psoriasis that is commonly seen in adults. Pustular psoriasis is an uncommon form of psoriasis consisting of widespread pustules on an erythematous background, as shown in the image below. The acute generalized type is also termed von Zumbusch variant. A disproportionately high number of cases are found in the pediatric population. Rare pathogenic variants in IL36RN underlie a spectrum of psoriasis-associated pustular phenotypes. Among all types of psoriasis, congenital psoriasis appears to be rare (14). Pustular psoriasis in children has often a better clinical progression than adults considered as a life-threatening disease. Superficial and sterile pustules may be localized or generalized.
For generalized pustular psoriasis, systemic agents such as retinoids may be required from the beginning of treatment. Children 2-10 years of age can be affected, but this is rare. Generalized pustular psoriasis: This is a rare form of psoriasis is also known as von Zumbusch psoriasis. Psoriasis often undiagnosed cause of skin symptoms in children: Children who suffer from the skin disorder called psoriasis can often go undiagnosed. Pustular psoriasis is a more rare type of psoriasis causing pus-filled blisters or pustules on the skin. It can affect children aged two to 10 years, but this is rare, and when it does boys are affected somewhat more often than girls.
Generalized Pustular Psoriasis Masquerading As Subcorneal Pustular Dermatosis In A Child Rao R, Prabhu S, Sripathi H, Shenoi S D
Generalized pustular psoriasis (GPP) is a rare condition in young children. It is difficult to treat and may require long-term systemic therapy. We report the long-term course of a 3-year-old boy whose onset of psoriasis dated to age 7 months.