Long-term metabolic effects of bariatric surgery in obese patients with type 2 diabetes mellitus. The role of intestinal vs. gastric mechanisms in the regulation of body weight and glucose homeostasis. F.K. Gastric bypass surgery: improving psoriasis through a GLP-1-dependent mechanism?. The density of Iba1- and IB4-immunoreactivity was analyzed using Nikon Elements software. Results of our study provide a deeper understanding of the role of the neural component in the mechanism of RYGB and show that damage of vagal innervation, to the stomach, produces reorganization of feeding centers in the brain. Knop, Gastric bypass surgery: improving psoriasis through a GLP-1-dependent mechanism? Gastric bypass surgery: improving psoriasis through a GLP-1-dependent mechanism?
A: in RYGBP, nutrients rapidly pass through the small gastric pouch, by-passing the majority of the stomach and upper small bowel and directly entering the mid-jejunum. Although the mechanisms promoting the sustained weight loss and T2D amelioration, after RYGBP and SG, remain incompletely understood (84), gut hormones have been consistently proposed as key effectors of the physiological changes induced by these procedures (86, 104, 107, 132). Of key relevance to bariatric surgery, the contribution of GLP-1 to the incretin effect increases exponentially with increasing rate of glucose delivery to the intestine, whereas GIP appears to contribute more at low glucose delivery rates (88). Improvement of psoriasis during exenatide treatment in a patient with diabetes. Obesity and the metabolic syndrome in pediatric psoriasis. Knop, F.K. Gastric bypass surgery: Improving psoriasis through a GLP-1-dependent mechanism? Gastric bypass surgery: improving psoriasis through a GLP-1-dependent mechanism? Faurschou A, Zachariae C, Skov L, Vilsbll T, Knop FK.
We observed an improvement in psoriasis severity in a patient within days of starting treatment with an incretin-mimetic, glucagon-like peptide-1 (GLP-1) receptor agonist. The GLP-1 receptor was expressed on iNKT cells, and GLP-1 induced a dose-dependent inhibition of iNKT cell cytokine secretion, but not cytolytic degranulation in vitro. Long-acting GLP-1 analogues, GLP-1 receptor agonists and inhibitors of GLP-1 enzymatic degradation are increasingly used in type 2 diabetes to improve glycaemic control and enhance weight loss. GLP-1 modulates iNKT cell cytokine production in a GLP-1R-dependent manner. Mechanisms of improved glycaemic control after Roux-en-Y gastric bypass. Metabolic surgery: an evolution through bariatric animal models. Exaggerated glucagon-like peptide-1 and blunted glucose-dependent insulinotropic peptide secretion are associated with Roux-en-Y gastric bypass but not adjustable gastric banding. Weight loss interventions, including bariatric surgery, can effectively reduce weight and improve renal outcomes. We will discuss the pitfalls in assessing renal function in obese cohorts and will examine the effect of bariatric surgery on renal function and urinary protein excretion using different mechanisms.