Article: Comparison of the effects of vitamin D products in a psoriasis plaque test and a murine psoriasis xenograft model. FULL TEXT Abstract: The antipsoriatic effect of an innovative aerosol foam formulation of fixed combination calcipotriol 50 g/g (as hydrate; Cal) and betamethasone. Formulation of Fixed Combination Calcipotriol plus Betamethasone Dipropionate in Patients with Psoriasis Vulgaris. Background and Objective. Comparison of the effects of vitamin D products in a psoriasis plaque test and a murine psoriasis xenograft model. One example of such an analog with a good dissociation ratio is calcipotriol (DaivonexR), which is clinically used to treat the hyperproliferative skin disease psoriasis. Tacalcitol 6, calcipotriol 7 and the recently approved maxacalcitol 5 are used either as monotherapy or in combination with topical steroids such as betamethasone dipropionate to treat psoriasis. Various studies in mouse models as well as in patients show that treatment with eldecalcitol 9 leads to higher lumbar and hip bone mineral density and a lower incidence of new vertebral fractures (Ito et al. To unravel the exact working mechanisms of vitamin D analogs more research studies should compare the effects of vitamin D analogs in different cell types to the mother compound.
Physicochemical Information Dimensions Materials Information Toxicological Information Safety Information according to GHS Safety Information Product Usage Statements Usage Statement Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. The antipsoriatic effect of an innovative aerosol foam formulation of fixed combination calcipotriol 50 g/g (as hydrate; Cal) and betamethasone 0. This was a Phase IIa, single-centre, investigator-blinded, exploratory study, with intra-individual comparison using a modified psoriasis plaque test. The efficacy and safety of calcipotriol plus betamethasone dipropionate ointment in the treatment of psoriasis vulgaris has consistently been demonstrated in several clinical trials. Through further modification of this method, the efficacy between antipsoriatic products can be differentiated.